Precore/core mutations of hepatitis B virus genotype D arising in different states of infection.
PMID: 35415256
2022
Clinical and experimental hepatology
Result: The G29D substitution detected in 32% (25/73) of the subjects was the second one, but its frequency among the studied groups was also not significant (p = 0.19).
Discussion: In this regard, a meta-analysis study showed a significant correlation between G29D mutation and higher risk of HCC.
Discussion: Our results also showed G29D precore mutation at the highest frequency in the C/HCC group among the groups, but the difference was not statistically significant.
Hepatitis B virus precore/core region mutations and genotypes among hepatitis B virus chronic carriers in South-Eastern, Nigeria.
PMID: 33708042
2021
International journal of health sciences
Discussion: The G1899A precore mutation causing the amino acid variation G29D have also been reported to be significantly associated with the development of cirrhosis and HCC.
Discussion: This mutation caused a change from guanine to adenine at nucleotide 1899 which resulted to a glycine to aspartic acid amino acid substitution at residue 29 of the precore region.
The Correlation Between Hepatitis B Virus Precore/Core Mutations and the Progression of Severe Liver Disease.
PMID: 30406036
2018
Frontiers in cellular and infection microbiology
Abstract: Two precore mutations, W28* and G29D, and six core mutations, F24Y, E64D, E77Q, A80I/T/V, L116I, and E180A were significantly associated with the development of cirrhosis and HCC.
Discussion: An
Discussion: Similarly, the present analysis identified a significant positive association between the mutation G29D and progression toward severe liver disease in HBV-infected Saudi patients.
Lower mutation frequency of BCP/precore regions in e antigen-negative chronic HBV-infected children instead of adults patients.
Discussion: Although the G1899A mutation only changes the glycine at codon 29 into aspartic acid and is always accompanied by the G1896A mutation, a previous study revealed that approximately 50% of the HBeAg negative variants contained this combined mutation.
Naturally occurring precore/core region mutations of hepatitis B virus genotype C related to hepatocellular carcinoma.
Abstract: Six (preC-W28*, C-P5H/L/T, C-E83D, C-I97F/L, C-L100I and C-Q182K/*) and seven types (preC-W28*, preC-G29D, C-D32N/H, C-E43K, C-P50A/H/Y, C- PMID: 8835351
1996
Journal of medical virology
Abstract: One was located in the pre-surface 1 gene; two were in the surface gene; three were in the pre-core gene, including codons 28 (tryptophan to stop codon) and 29 (glycine to aspartic acid); eight were in the core gene; and 11 were in the polymerase gene.
[Detection of hepatitis B virus by using polymerase chain reaction and nonradioactive DNA probes. I. Identification of mutations in the precore region by PCR-direct sequencing and ASO probe method].
PMID: 7474444
1995
Rinsho byori. The Japanese journal of clinical pathology
Abstract: Five unknown mutations (I10N, C12W, C14S, V17F and A19D), three known mutations (I9V, W28X and G29D) and for novel nucleotide insertions were identified in anti-HBe positive sera.
The mechanism of natural occurrence of two closely linked HBV precore predominant mutations.
Abstract: Double amino acid substitutions were seen in the precore region in the isolates: one from glycine to aspartic acid at codon 29 previously reported; the other substitution of phenylalanine for valine at codon 17 in the cleavage site of hepatitis B virus.
HBV mutation literature information.
PMID: 
2022
Clinical and experimental hepatology
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