literature

HBV mutation literature information.

Qidong hepatitis B virus infection cohort: a 25-year prospective study in high risk area of primary liver cancer.

PMID: 29479565 2018 Hepatoma research

Abstract: A series of novel PLC-related mutations including A2159G, A2189C and G2203W at the C gene, A799G, A987G and T1055A at the P gene of HBV genome were identified by using samples from the cohort.

Introduction: These mutations include A2159G, A2189C and G2203W at C gene, A799G, A987G and T1055A at P gene, and A1479T at X gene.

Potential Susceptibility Mutations in C Gene for Hepatitis B-Related Hepatocellular Carcinoma Identified by a Two-Stage Study in Qidong, China.

PMID: 27727182 2016 International journal of molecular sciences

Discussion: In accordance with the results of Zhu et al., in the present study, we confirmed that A21

Discussion: In the present study, the risk of combined mutations in the C gene, including the A2159G, A2189Y, G2203W, and C2288R mutations, on HCC was explored.

Discussion: The key finding of this study was that the number and pattern of multiple mutations in the C gene (A2159G, A2189Y, G2203W, and C2288R mutations) showed the additive combined effects that related to HCC progression.

Novel natural mutations in the hepatitis B virus reverse transcriptase domain associated with hepatocellular carcinoma.

PMID: 24788140 2014 PloS one

Introduction: Over the past few years, we defined that a high prevalence of the HBV C1 genotype, pre-S deletion and pre-S2 start codon mutation, C1653T, T1753A/G, C1766T, and T1768A mutations in the BCP/EnhII region, and A2159G, A2189C, and G2203W in the core gene are associated with HCC in Qidong.

Hepatitis B virus core promoter mutations G1613A and C1653T are significantly associated with hepatocellular carcinoma in genotype C HBV-infected patients.

PMID: 22014121 2011 BMC cancer

Discussion: A recent study from China revealed that 1613 and 1653 mutations were included in mutations frequently detected in HCC patients; however, core region mutants A2189C and G2203W were independent risk factors for HCC.

Comparison study on the complete sequence of hepatitis B virus identifies new mutations in core gene associated with hepatocellular carcinoma.

PMID: 20699378 2010 Cancer epidemiology, biomarkers & prevention

Abstract: In the validation study, A2159G, A2189C, and G2203W showed consistent associations with HCC by univariate analysis.

Abstract: Multivariate analysis showed that A2189C and G2203W were independent risk factors for HCC.

Abstract: RESULTS: The pre-S deletion and 12 point mutations, namely, the pre-S2 start codon mutation, T53C in the pre-S2 gene, T766A in the S gene, G1613A, C1653T,

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