New point mutations in surface and core genes of hepatitis B virus associated with acute on chronic liver failure identified by complete genomic sequencing.
Discussion: Also it was found that the frequencies of T216C, G1896A, G1913A/G, and A2159G/C were >45% in the patients with ACLF, the combinative mutations at these sites could be utilized to diagnose clinically and to discriminate the HBV-infected patients with advanced disease.
HBV mutation literature information.
PMID: 
2015
PloS one
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