Abstract: OBJECTIVE: To investigate the relationship between mutations of rtM204V/I (methionine to valine or isoleucine at position rt204 of reverse transcriptase domain) in the hepatitis B virus (HBV) polymerase gene and the G1896A and G1899A single mutations in the pre-eore (PC) region and the A1762T and G1764A double-mutations in the basal core promoter (BCP) region.
Abstract: Of the 1543 strains (54.2%) with PC-BCP mutations, seven mutation patterns of
Combinations of eight key mutations in the X/preC region and genomic activity of hepatitis B virus are associated with hepatocellular carcinoma.
Abstract: Accumulation of eight key mutations located in the X/preC regions of the hepatitis B virus (HBV) genome (G1613A, C1653T, T1753V, A1762T, G1764A, A1846T, G1896A and G1899A) is a risk marker for the development of hepatocellular carcinoma (HCC).
Molecular characterization of HBV strains circulating among the treatment-naive HIV/HBV co-infected patients of eastern India.
Result: Similarly, the precore stop codon mutation (G1896A) occurred in 13 isolates (13/59, 22%) with all harboring the C1858T mutation and in 4 cases it occurred along with G1899A mutation.
Analysis of complete nucleotide sequences of Angolan hepatitis B virus isolates reveals the existence of a separate lineage within genotype E.
Result: The common variations A1762T-G1764A in the basal core promoter and G1896A and G1899A in the precore region were identified in three, four and two isolates, respectively.
Table: G1899A
Novel natural mutations in the hepatitis B virus reverse transcriptase domain associated with hepatocellular carcinoma.
Introduction: In addition, A2159G and A2189C in the core gene and G1896A and
Discussion: Another possibility to explain the rationality of A987G is that this mutation may be in linkage disequilibrium with other well-defined HCC-related mutations such as pre-S deletion, the BCP/EnhII region mutations C1653T, T1753A/G, C1762T, and T1764A, and the precore mutations G1896A, G1899A.
Mother-to-child transmission of hepatitis B virus: evolution of hepatocellular carcinoma-related viral mutations in the post-immunization era.
Abstract: The study confirmed that core promoter and precore mutations occur at key positions (A1762T, G1764A, G1896A, and G1899A), and that the proportions of strains with seroconvertion in patients differ between the four HBV genotypes.
Prevalence of mutations in basal core promoter and precore region of hepatitis B virus in vaccinated and nonvaccinated individuals of the aboriginal Nicobarese tribe of Car Nicobar Island, India.
Abstract: Among the nonvaccinated subjects, 3 (4.5%) had an A1762T mutation, 8 (12.1%) had a G1764A mutation, 11 (16.7%) had a G1896A mutation and 4 (6.1%) had a G1899A mutation.
Association of Hepatitis B Virus Mutations of A1846T and C1913A/G With Acute-on-Chronic Liver Failure Development From Different Underlying Chronic Liver Diseases.
Abstract: In addition, there were no significant differences in mutations at T1753V, A1762T, G1764A, G1896A, and G1899A which were found between either CHB and ACLF-CHB or LC and ACLF-LC patients, suggesting no associations of these mutations with ACLF development.
Introduction: Also, genotypes B, T1753V, and G1899A were more frequently found in ACLF pa
A complete genomic analysis of hepatitis B virus isolated from 516 Chinese patients with different clinical manifestations.
Abstract: Incidences of point mutation T53C (preS1F53L), G1613A (polR841K), G1775A and A1762T + G1764A in the basal core promoter region, G1896A and G1899A in precore region and A2189C (coreI97L) in core region increased along with acute hepatitis B, chronic hepatitis B, and acute-on-chronic liv
HBV mutation literature information.
PMID: 
2014
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