Hepatitis B virus subgenotype C2- and B2-associated mutation patterns may be responsible for liver cirrhosis and hepatocellular carcinoma, respectively.
PMID: 23903686
2013
Brazilian journal of medical and biological research
Introduction: In addition, study of C1653T, T1753V, G1899A, and other mutations in the enhII/BCP/precore regions has just begun.
Effects of hepatitis B virus mutations on its replication and liver disease severity.
Introduction: G1899A mutations increased DNA replication but the double mutation G1899A/G1862T was associated with considerably more replication compared to G1862T alone.
Introduction: Interestingly, U:G pair is converted into U:A in the lower stem (epsilon) in the two positions 1855/1899 if HBV strain possesses G1899A mutation.
Discussion: G1899A mutation has an interesting effect on the pair of 1855 position.
Discussion: Conversely, they presented enhancement of the same protein for G1899A.
Variability of the preC/C region of hepatitis B virus genotype A from a South African cohort predominantly infected with HIV.
Discussion: G1899A found in participant 3319 has been reported in patients with fulminant hepatitis failure and has also been found in high frequency in hepatocellular carcinoma (HCC), liver cirrhosis, and chronic hepatitis.
Mutational complex genotype of the hepatitis B virus X /precore regions as a novel predictive marker for hepatocellular carcinoma.
Abstract: For combined mutations, A1762T+G1764A (23.43% vs. 11.59 %, p<0.05) and G1896A+ G1899A (21.88% vs. 13.04%, p<0.05) were significantly more frequent in ACLF-HBV than CHB patients.
HBV Subgenotype C2 Infection, A1762T/G1764A Mutations May Contribute To Hepatocellular Carcinoma with Cirrhosis in Southeast China.
PMID: 23304671
2012
Iranian journal of public health
Introduction: HBV mutations were often observed in the pre-C and basal core promoter (BCP) regions, such as T1753C, A1762T, G1764A, G1862T, G1896A and G1899A nucleotide acid substitution.
[Analysis of the relationship between hepatitis B virus precore and basal core promoter mutations and acute-on-chronic liver failure].
Abstract: Mutations G1899A, T1753V, and A1846T were correlated with disease recovery.
Abstract: Single mutations (A1762T, G1764A, T1753V, G1896A, and G1899A) and combined mutations (A1762T + G1764A, G1896A + G1899A, T1753V+ A1762T + G1764A, G1896A + G1899A + A1762T + G1764A, and PMID: 22997074
2012
Journal of medical virology
Abstract: G1896A (74.8%), G1764A/T/C (71.5%), G1899A (54.4%) and T1678C (52%) were the most common.
Abstract: High DNA levels were associated with G1899A or G1764T/C-C1766G-C1799G and advanced liver disease with mutations at positions 1762, 1764 and/or 1899 alone or in double or triple mutations.
Variability in the precore and core promoter regions of HBV strains in Morocco: characterization and impact on liver disease progression.
Introduction: Our previous study focused only on pre-C G1896A and G1899A mutations by using selective oligonucleotide hybridization, and showed a predominance of these variants.
Introduction: Recently, additional mutations in the pre-C and CP regions, including G1899A, C1653T, T1753V, C1766T and T1768A have become increasingly recognized to be associated with severe clinical outcome and HCC development.
Result: As shown in Figure 1, G1896A and G1899A were more common in g
Hepatitis B virus gene mutations in liver diseases: a report from New Delhi.
HBV mutation literature information.
PMID: 
2013
Brazilian journal of medical and biological research
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