Abstract: CONCLUSIONS: Precore mutation G1896A, G1899A, deletions in Pre-S region as well as the other commonly seen mutations correlated with the increased risk of HCC, especially in Asians and may predict the progression of the liver disease.
Abstract: Statistically significant correlations were observed in Precore mutation G1896A (OR = 1.46, 95% confidence interval [CI] = 1.15-1.85, P(OR) = 0.002), G1899A (OR = 3.13, 95%CI = 2.38-4.13, P(OR)<0.001) and Pre-S mutation especially Pre-S1 deletion (OR = 2.94, 95%CI = 2.22 to 3.89) and
Quantitative dynamics of hepatitis B basal core promoter and precore mutants before and after HBeAg seroconversion.
4Method: Only the G1896A and G1896A/G1899A mutations are designated as the ""precore mutations""."
4Method: The G1899A mutation alone (in the absence of G1896A mutation) has not been reported to affect HBeAg production, thus it was not counted as t
Introduction: We have recently overcome this technical difficulty and established reliable quantitative assays for the detection of the BCP A1762T/G1764A double mutation and the precore mutations (G1896A and G1896A/G1899A).
Full genome characterization of hepatitis B virus strains from blood donors in Iran.
Abstract: The molecular analysis of the individual genes revealed that the G1896A mutation was present in 86.2% of the strains and in 26 strains (29.9%) this mutation was accompanied by the G1899A mutation.
Quantification of complex precore mutations of hepatitis B virus by SimpleProbe real time PCR and dual melting analysis.
Abstract: OBJECTIVES: (1) To develop a reliable and ultrasensitive assay for the quantification of HBV G1896A and/or G1899A mutants.
Abstract: This mutation and the adjacent G1899A mutation also appear to associate with increased risk of hepatocellular carcinoma.
Introduction: It was shown that the appearance of G1896A or G1899A mutation in the precore region correlated with increased risk of HCC, although inconsistent results were also reported.
Met
Method: A two-step assay was developed for the quantification of G1896A and/or G1899A mutants with high sensitivity.
A case-control study on sequence variations in the enhancer II/core promoter/precore and X genes of hepatitis B virus in patients with hepatocellular carcinoma.
Abstract: By multiple logistic regression analysis, the presence of cirrhosis, A1762T/G1764A and G1899A mutations were independently associated with the risk of HCC.
Abstract: CONCLUSION: These data suggested that A1762T/G1764A and G1899A mutations were associated with the development of HCC in Thai patients.
Abstract: RESULTS: The prevalence of T1753C/A, A1762T/G1764A and G1899A mutations were significantly higher in the PMID: 20699378
2010
Cancer epidemiology, biomarkers & prevention
Abstract: RESULTS: The pre-S deletion and 12 point mutations, namely, the pre-S2 start codon mutation, T53C in the pre-S2 gene, T766A in the S gene, G1613A, C1653T, A1762T, G1764A in the X gene, and G1899A, C2002T, A2159G, A2189C, and G2203W (A or T) in the pre-C/C gene, showed close associations with
High frequency of lamivudine resistance mutations in Brazilian patients co-infected with HIV and hepatitis B.
Abstract: Mutations in the BCP region (A1762T, G1764A) and in the precore region (G1896A, G1899A) were also found.
Features and clinical implications of hepatitis B virus genotypes and mutations in basal core promoter/precore region in 507 Chinese patients with acute and chronic hepatitis B.
Abstract: Significantly lower prevalence of A1762T, G1764A, G1896A, and G1899A but higher prevalence of T1758C was found in AHB patients.
Hepatitis B virus genotype and basal core promoter/precore mutations are associated with hepatitis B-related acute-on-chronic liver failure without pre-existing liver cirrhosis.
Abstract: Single mutations including T1753V (C/A/G), A1762T, G1764A, G1896A and G1899A and triple mutations T1753V/A1762T/G1764A and A1762T/G1764A/C1766T (or T1768A) were more frequently detected in patients with HB-ACLF than in patients with CHB.
Introduction: In addition, single mutations including the T1753V (C/A/G),
Table: G1899A
Associations between hepatitis B virus mutations and the risk of hepatocellular carcinoma: a meta-analysis.
PMID: 19574418
2009
Journal of the National Cancer Institute
HBV mutation literature information.
PMID: 
2012
PloS one
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