Result: Finally, the 1899 G to A substitution (codon 29 of the precore), previously shown to enhance the pregenomic RNA transcription, was found in a single isolate (D5).
Incidence and clinical significance of hepatitis B virus precore gene translation initiation mutations in e antigen-negative patients.
Abstract: In one of eight patients in addition to wildtype HBV a mutant strain (nt. 1899 G-->A) was detected.
Abstract: Six of nine patients of group B were reinfected with the same mutant population; in one, an additional pre-core mutation emerged; two patients lost pre-core mutant HBV (nt. 1896 and 1899 G-->A).
Detection of hepatitis B precore mutants by the fluorescent linear polymerase chain reaction sequencing method.
Abstract: Precore variants were detected in one HBeAg positive and in all 20 anti-HBe positive patients: in 19 cases, G to A at position 1896, with or without the substitution G to A at position 1899, in two cases C to T substitution at position 1817 which also produces a stop codon (CAA to TAA), one accompanied by the mutation G to A at position 1896.
Abstract: The only mutation observed in the patient who was initially HBeAg positive patient was a G to A substitution at position 1899.
Mutations in the pre-core region of hepatitis B virus serve to enhance the stability of the secondary structure of the pre-genome encapsidation signal.
Abstract: Four major missense/nonsense mutations (M) were found: (M1) C-->T at nucleotide position 1856, Pro-->Ser at codon 15; (M2) G-->A at position 1896, Trp-->stop at codon 28; (M3) G-->A at position 1898, Gly-->Ser at codon 29; and (M4) G-->A at position 1899, Gly-->Asp at codon 29.
Detection of precore hepatitis B virus mutants in asymptomatic HBsAg-positive family members.
Abstract: We previously reported two novel mutations: M1 (C-to-T change at nucleotide 1856 [proser at codon 15]) and M3 (G-to-A change at nucleotide 1898 [gly-ser at codon 29]) in addition to two well-described mutations: M2 (G-to-A change at nucleotide 1896 [trp-stop at codon 28]); and M4 (G-to-A change at nucleotide 1899 [gly-asp at codon 29]) in Chinese patients.
HBV mutation literature information.
PMID: 
2001
BMC microbiology
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