Abstract: After treatment, the detection rate of the above mutation sites decreased, but C1653T, C1673T and G1899A were not detected.
Abstract: Patients C, B, C, B, and C were examined for C1673T, G1896, G1858, G1899A.
Basal core promoter and precore mutations among hepatitis B virus circulating in Brazil and its association with severe forms of hepatic diseases.
PMID: 28902288
2017
Memorias do Instituto Oswaldo Cruz
Result: BCP and PC mutations and forms of chronic HBV infection - Among the 129 patients in whom the HBV PC region was analysed, a high frequency of HBV strains with G1896A mutation (53/129, 41%) was detected, alone or in G1896A/G1899A double mutation, particularly in the subgroup with HBeAg-negative chronic hepatitis (39/85, 45.9%) (p = 0.03).
Table: G1899A
Differential regulation of hepatitis B virus core protein expression and genome replication by a small upstream open reading frame and naturally occurring mutations in the precore region.
Result: Comparison of alphalM0, F (alphalM0 with mutated precore ATG), and alphal in the same blot indicates that G1896A/G1899A were more effective than mutated precore ATG in augmenting core protein expression, although ol+36 did not show
Discussion: Among HBeAg-negative precore mutations tested, G1896A in conjunction with G1899A was more effective than mutated precore ATG at increasing core protein expression.
Discussion: Both the G1896A and G1899A mutations convert a U:G pair in stem I into a UA pair.
Hepatitis B virus sequencing and liver fibrosis evaluation in HIV/HBV co-infected Nigerians.
PMID: 28376292
2017
Tropical medicine & international health
Result: Twenty patients (57%) had PC G1896A mutations and 12 (34%) had PC G1899A mutations.
Phenotypic and Genotypic Shifts in Hepatitis B Virus in Treatment-Naive Patients, Taiwan, 2008-2012.
Abstract: Over time, we observed substantial decreases in the prevalence of HBV e antigen (HBeAg) and increasing prevalence of the precore G1899A mutation and HBV-DNA levels in HBeAg-positive patients.
Conclusion: On the other hand, prevalence of G1899A mutations increased from 2.5% to 17.4%.
Conclusion: Over the 5 years of this study, we found an increasing prevalence of G1899A mutations and an increasing concentration of serum HBV DNA in treatment-naive, HBeAg-positive patients.
Method: Alternatively, dependent on the scale of antiviral drug treatment received in this population, the therapeutic methods might also partly contribute to selection of mutation PMID: 28859616
2017
BMC infectious diseases
Method: Mutations in the BCP (C1653T, T1674C/G, T1753 V, A1762T, G1764/A, C1766T, and T1768A) and the PC/core region (G1899A, C2002T, A2159G, A2189C, and G2203A/T) associated with HCC were also analyzed.
Table: G1899A
Association between hepatitis B virus basal core promoter/precore region mutations and the risk of hepatitis B-related acute-on-chronic liver failure in the Chinese population: an updated meta-analysis.
Abstract: CONCLUSIONS: HBV T1753V, A1762T/G1764A, A1846T, G1896A, and G1899A mutations are correlated with an increase in the risk of HB-ACLF.
Abstract: Statistically significant summary ORs for HB-ACLF were obtained for T1753V (1.99; 95 % confidence interval 1.30-3.02) and A1762T/G1764A (2.11; 95 %, 1.75-2.54) in the BCP region and for A1846T (3.33; 95 %, 2.23-4.97), G1896A (2.78; 95 %, 2.07-3.74), and G
Hepatitis B virus basal core promoter/precore mutants and association with liver cirrhosis in children with chronic hepatitis B virus infection.
PMID: 26577140
2016
Clinical microbiology and infection
Abstract: Among all the patients with genotype B viruses, those with LC had lower HBV DNA levels and higher G1899A mutation frequency than patients with CHB.
Hepatitis B virus basal core promoter mutations show lower replication fitness associated with cccDNA acetylation status.
Abstract: HBV monomers bearing BCP mutations A1762T/G1764A and A1762T/G1764A/C1766T, and precore mutations G1896A, G1899A and G1896A/G1899A, were transfected into HepG2 cells using a plasmid-free approach.
Different precore/core mutations of hepatitis B interact with, limit, or favor liver fibrosis severity.
PMID: 26992056
2016
Journal of gastroenterology and hepatology
Abstract: Interestingly, the association of the G1899A mutation with the double A1762T/G1764A mutant significantly counteracted the deleterious effect of the sole double A1762T/G1764A mutant (odds ratio [OR] = 0.28 vs.
Abstract: METHODS: Direct sequencing of the precore/core gene was used to detect A1762T/G1764A and G1757A mutations in the BCP and G1896A and G1899A mutations in the PC region.
HBV mutation literature information.
PMID: 
2018
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