Spontaneous reactivation of hepatitis B virus with a frameshift mutation in the precore region in an elderly hepatitis B virus carrier with lifestyle-related diseases.
PMID: 33959934
2021
Clinical journal of gastroenterology
Abstract: Her HBV genome was typed as subgenotype B1 and possessed a frameshift mutation due to an insertion of T after nucleotide (nt) 1817 and G to A mutations at nt 1896 and nt 1899 (G1896A/G1899A) in the precore region as well as serine to glutamine substitution of amino acid 21 in the core protein.
Hepatitis B virus precore/core region mutations and genotypes among hepatitis B virus chronic carriers in South-Eastern, Nigeria.
PMID: 33708042
2021
International journal of health sciences
Result: An assessment of the distribution of HBV precore/core region specific mutations among the HBV genotypes in Table 2 showed that there exists a significant statistical difference between the occurrence of G1862C, G1888A, and G1899A specific mutations among the HBV subgenotype A1 and genotype D infected participants (P < 0.05, Fisher's exact test).
Result: However, a trend toward statistical significance was observed in the difference between the median of HBV DNA and AFP levels among the participants with the G1899A mutation (P = 0.057 and P = 0.056, respectively), where a higher median value was observed among those with the mutant strains for both HBV DNA and AFP levels [Tables 3 and 4].
Discussion: A missense mutation observed in this study is the PMID: 33458253
2020
Wellcome open research
Conclusion: The most prevalent minority variant mutations in our HBV sequences were G1896A, G1899A and G1764A (precore/core and basal core promotor sequences respectively) ( Table 1).
Table: G1899A
Quadruple mutation GCAC1809-1812TTCT acts as a biomarker in healthy European HBV carriers.
Method: For control of the assays, a GTA HBeAg-negative genome with precore double mutation G1896A/G1899A, a GTA HBeAg-positive genome.
Result: The specificity of the blot was proven by using an additional genome containing the precore double mutation G1896A/G1899A, which was used as an additional HBeAg negative control, and by using an HBeAg positive WT genome as a positive control (Figure 3A).
Virological Factors Associated With the Occurrence of Hepatitis B Virus (HBV) Reactivation in Patients With Resolved HBV Infection Analyzed Through Ultradeep Sequencing.
PMID: 31550370
2020
The Journal of infectious diseases
Abstract: The population of S3N amino acid substitution and nucleotide G1896A and G1899A mutations in each individual showed a similar percentage of occurrence.
Abstract: The prevalence of the S3N amino acid substitution in the envelope protein and mutations at positions G1896A and G1899A in the precore region were significantly higher in the HBVr compared with AHB.
Large-scale viral genome analysis identifies novel clinical associations between hepatitis B virus and chronically infected patients.
Result: Our unbiased approach led us to the discovery of additional variants highly associated with patient's HBeAg status: G1899A, A1838G, T2045A, G2345A, G2352A, T2441C, A2189C, T2443C, C1962A, G2237C, and others (LRT; p < 9.55 x 10-13.
Result: Variants G1896A and G1899A, on the other hand, impact the base pairing of the stem structure within the epsilon region of the pgRNA, affecting the secondary RNA structure and consequently the encapsidation of the pgRNA, a crucial step prior to the generation of the rcDNA.
Nucleotide Substitutions in Hepatitis B Viruses Derived from Chronic HBV Patients.
PMID: 31308922
2019
Mediterranean journal of hematology and infectious diseases
Abstract: The PC and BCP mutations were G1896A (61.0%), G1899A (23.0%), A1762T/G1764A (23.0%) and G1764T/C1766G (26.0%).
Result: The G1899A mutation was found in 6 (23.0%) isolates and had concomitant G1896A change.
Discussion: In this study, another common pre-core mutation at
Discussion: It was observed that all subjects with the G1899A variant carried G1896A.
Discussion: Our finding is comparable with a study which showed G1899A in 29.3% of patients.
The mutation of hepatitis B virus and the prognosis of hepatocellular carcinoma after surgery: a pilot study.
PMID: 29628773
2018
Cancer management and research
Result: As shown in Tables S1, S2, and S3, the A1762T/G1764A mutation is correlated with tumor size (r=0.204, p=0.019), G1899A mutation with vascular invasion (r=0.332, p<0.001), and Pre S deletion with AFP (r=0.254, p=0.003), positively.
Result: However, A1762T/G1764A mutation related to worse OS and DFS (p=0.040 and p=0.006, respectively), G1899A mutation related to worse OS (p=0.030), and Pre S deletion mutation related to worse OS and DFS (p<0.001 and p<0.001, respectively, Table 2, Figure 1).
Result: The relationships between A1762T/G1764A, G1899A, and PMID: 29408943
2018
PloS one
Table: G1899A
A new hepatitis B virus e antigen-negative strain gene used as a reference sequence in an animal model.
PMID: 29339154
2018
Biochemical and biophysical research communications
Abstract: The main four point variants including A1762T, G1764A, G1896A, and G1899A were detected in the full-length genome.
Abstract: The strain will increase viral replication and infection for mutations A1762T and G1764A in the basal core promoter region, and mutations G1896A and G1899A in the pre-core region.
HBV mutation literature information.
PMID: 
2021
Clinical journal of gastroenterology
Browser Board
Co-occurred Entities
Filtrator
ViMRT