literature

HBV mutation literature information.

The mutation of hepatitis B virus and the prognosis of hepatocellular carcinoma after surgery: a pilot study.

PMID: 29628773 2018 Cancer management and research

Method: According to the sequencing outcome, HBV genotype and mutations (including A1752T/G, T1753C, G1757A, A1762T/G1764A, C1766T, T1768A, A1775G, C1799G, A1846T, T1858C, G1896A, G1898A, G1899A, and Pre S deletion) were confirmed by the BLAST analysis (http://blast.ncbi.nlm.nih.gov/Blast.cgi).

Result: According to different mutation regions, A1752T/G, T1753C,

Variability in the precore and core promoter region of the hepatitis B virus genome.

PMID: 24249691 2014 Journal of medical virology

Abstract: A rare double mutation (C1857T together with G1897A) was observed, and C1856T was found together with the emerging G1898A mutation, which itself was found to be more widespread geographically than previously described.

Quantification of complex precore mutations of hepatitis B virus by SimpleProbe real time PCR and dual melting analysis.

PMID: 21665530 2011 Journal of clinical virology

Result: Mutations at nt 1896-1899 were limited to G1896A, G1899A, G1896A/G1899A or their mixtures, with the exception of 2 cases in which G1898A was detected.

Associations between hepatitis B virus mutations and the risk of hepatocellular carcinoma: a meta-analysis.

PMID: 19574418 2009 Journal of the National Cancer Institute

Table: G1898A

Phylogenetic, virological, and clinical characteristics of genotype C hepatitis B virus with TCC at codon 15 of the precore region.

PMID: 16517839 2006 Journal of clinical microbiology

Abstract: HBV with TCC at nucleotides 1856 to 1858 was associated with the G1898A mutation (64%).

[In vitro expression of wild type and precore mutant woodchuck hepatitis virus].

PMID: 15619810 1997 Zhonghua shi yan he lin chuang bing du xue za zhi

Abstract: Hepatitis B virus (HBV) precore 1896 and 1898 G-->A mutations are regarded as hot spots to study.

Mutations in the pre-core region of hepatitis B virus serve to enhance the stability of the secondary structure of the pre-genome encapsidation signal.

PMID: 8171038 1994 Proc Natl Acad Sci U S A

Abstract: Four major missense/nonsense mutations (M) were found: (M1) C-->T at nucleotide position 1856, Pro-->Ser at codon 15; (M2) G-->A at position 1896, Trp-->stop at codon 28; (M3) G-->A at position 1898, Gly-->Ser at codon 29; and (M4) G-->A at position 1899, Gly-->Asp at codon 29.

Detection of precore hepatitis B virus mutants in asymptomatic HBsAg-positive family members.

PMID: 8188166 1994 Hepatology (Baltimore, Md.)

Abstract: We previously reported two novel mutations: M1 (C-to-T change at nucleotide 1856 [proser at codon 15]) and M3 (G-to-A change at nucleotide 1898 [gly-ser at codon 29]) in addition to two well-described mutations: M2 (G-to-A change at nucleotide 1896 [trp-stop at codon 28]); and M4 (G-to-A change at nucleotide 1899 [gly-asp at codon 29]) in Chinese patients.

Association of hepatitis B viral precore mutations with fulminant hepatitis B in Japan.

PMID: 1926786 1991 Virology

Abstract: We demonstrated that patients with fulminant hepatitis B carried HBV genomes with a G to A mutation at nucleotide positions 1898 (five of five patients; 18 of 18 clones, 100%) and 1901 (five of five patients; 12 of 18 clones, 66%) in the precore region.

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