Investigation of DNA sequence in the Basal core promoter, precore, and core regions of hepatitis B virus from Tunisia shows a shift in genotype prevalence.
Introduction: Several epidemiological studies have shown that HBV genotype D was predominant in the Tunisian population, and frequencies of double mutation A1762T /G1764A in BCP region and common mutation G1896A in PC region of viral B genome were higher among asymptomatic chronic carriers.
Result: Of limited number of 1858C variant virus examined in this study, none of them was found to have 1896A mutation when mutant G1896A was associated with double mutation A1850T and C1858T.
Result: Only 20 isolates out of 34 HBeAg-negative cases were found to have G to A mutation at nt 1896.
LCR based quick detection of hotspot G1896A mutation in patients with different spectrum of hepatitis B.
Abstract: As HBV infected blood donors were more often asymptomatic carriers, we could speculate that the G1896A mutation may favour the asymptomatic state, supporting previous observations.
Abstract: Three methods were used to detect G1896A mutation: non-commercial real-time PCR (PCRTR , line probe assay (InnoLiPA HBV PreCore, INNOGENETICS( )) and direct sequencing of precore gene.
Characterization of hepatitis virus B isolated from a multi-drug refractory patient.
Abstract: RESULTS: HBV precore/core gene mutation increased significantly more in the inflammatory phase than in the tolerance phase (G1896A, 76.2% versus 4.8%; C1913A, 33.3% versus 0%; C2189A, 28.6% versus 4.8%; G2304A, 52.4% versus 14.3%) in study group (n = 21) but not the control group (n = 9).
Natural history of chronic hepatitis B REVEALed.
PMID: 21323729
2011
Journal of gastroenterology and hepatology
Abstract: A significant association with risk of cirrhosis and HCC was also observed for HBV genotype, precore G1896A mutant and basal core promoter A1762T/G1764A double mutant.
Precore and core promoter mutations of the hepatitis B virus gene in chronic genotype C-infected children.
PMID: 21468263
2011
Journal of Korean medical science
Abstract: The precore (G1896A) and core promoter (A1762T, G1764A) mutations of the hepatitis B virus gene are known to be associated with changes in immunologic phase or the progression to complicated liver disease in adults.
Introduction: Discussion: In the precore gene, the guanine-to-adenine mutation at nucleotide 1896 (G1896A) is the most prevalent.
Discussion: The precore mutation (G1896A) was less prevalent than CP mutations (i.e., 5% of ICP patients, 32.5% of HBeAg negative carriers, and 22.5% of ITP patients).
Geographical and ethnic distribution of the HBV C/D recombinant on the Qinghai-Tibet Plateau.
Abstract: The predominance of the premature pre-core stop mutation G1896A in patients with the HBV C/D recombinant may account for the higher prevalence of HBeAg in these patients.
Abstract: Virologically HBV/CD1 had a significantly lower frequency of G1896A than HBV/C2.
Full genome characterization of hepatitis B virus strains from blood donors in Iran.
Abstract: The molecular analysis of the individual genes revealed that the G1896A mutation was present in 86.2% of the strains and in 26 strains (29.9%) this mutation was accompanied by the G1899A mutation.
T1846 and A/G1913 are associated with acute on chronic liver failure in patients infected with hepatitis B virus genotypes B and C.
HBV mutation literature information.
PMID: 
2012
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