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 HBV mutation literature information.


  Core promoter mutations 3 years after anti-hepatitis B e seroconversion in patients with chronic hepatitis B or hepatitis B and C infection and cancer remission.
 PMID: 12358268       2002       The American journal of gastroenterology
Abstract: The G1896A precore stop codon mutation was never observed.


  [Pre-Core mutation of HBV among 26 families with history of chronic HBV infection in Shenyang].
 PMID: 12665929       2002       Zhonghua shi yan he lin chuang bing du xue za zhi
Abstract: CONCLUSIONS: The G to A mutation at nucleotide 1896 in the pre C gene of HBV DNA could be associated with persistent HBV infection.
Abstract: METHODS: The G to A mutation at nucleotide 1896 in the pre C gene of HBV DNA was detected by PCR-RFLP.
Abstract: RESULTS: The results showed that the mutation rate of G to A mutation at nucleotide 1896 in the pre C gene of HBV DNA was much higher in patients (56.3%) and their family members (40.5%) than in their spouses (25.0%).


  A case-control study for clinical and molecular biological differences between hepatitis B viruses of genotypes B and C. Japan HBV Genotype Research Group.
 PMID: 11124839       2001       Hepatology (Baltimore, Md.)
Abstract: The predominance of mutants with G-to-A mutation at nucleotide (nt) 1896 in the precore region (A1896) over the wild-type was comparable between genotype B and C patients (60% and 62%, respectively), and it correlated with anti-HBe.


  Low frequency of mutations in the core promoter and precore regions of hepatitis B virus in anti-HBe positive Brazilian carriers.
 PMID: 11472634       2001       BMC microbiology
Abstract: BACKGROUND: Mutations in the core promoter and precore regions of the hepatitis B virus (HBV) genome, notably the double substitution (AGG to TGA) at nt positions 1762-1764 in the core promoter, and the precore stop codon mutation G to A at nt 1896, can often explain the anti-HBe phenotype in chronic carriers.
Result: The seven others (five from genotype D and two from genotype F) showed the 1896 G to A substitution leading to a stable T1858:A1896 base pairing and introducing a stop codon into the ORF of th
Discussion: The most common mutation was the G to A change at nt 1896 that creates a stop codon in the precore ORF.


  Phylogenetic origin of hepatitis B virus strains with precore C-1858 variant.
 PMID: 11526151       2001       Journal of clinical microbiology
Abstract: The predominant mutation, the precore G-->A-1896 mutation, is restricted by the variability at position 1858 and is rare in strains with cytosine at nucleotide 1858.


  Reactivation of latently infected hepatitis B virus in a leukemia patient with antibodies to hepatitis B core antigen.
 PMID: 11578069       2001       Journal of gastroenterology
Abstract: Mutation-specific assay based on competitive polymerase chain reaction (PCR) and sequencing analyses revealed the predominant reactivation of an HBV strain with missence mutation (point mutation G-to-A at nucleotide 1896) in the precore regions, as well as point mutations in the core promoter regions.


  Hepatitis B virus harboring nucleotide deletions in the core promoter region and genotype B correlate with low viral replication activity in anti-HBe positive carriers.
 PMID: 11595588       2001       Journal of clinical virology
Abstract: RESULTS: Various mutations were detected including C to T point mutation at nt 1653, A to T and G to A contiguous point mutations at nt 1762 and 1764 in the core promoter region, and G to A point mutation at nt 1896 in the precore region, but no common mutations were detected that were directly related to the virus titer from earlier reported mutations.


  Molecular analysis of hepatitis B virus genomes isolated from black African patients with fulminant hepatitis B.
 PMID: 11596083       2001       Journal of medical virology
Abstract: G1896A was, however, present in the one genotype D isolate.
Abstract: A relatively large number of mutations were present in the middle region of the core gene in those isolates without G1896A or A1762T, G1764A mutations, although the pattern was not consistent with those in published studies.
Abstract: The mutation most often reported in patients with fulminant hepatitis B, the G1896A precore stop-codon substitution, was, as expected, not present in the genotype A isolates with the exception of one in which it was accompanied by a compensatory C1858T substitution.


  Hepatitis B virus genomes of chronic hepatitis patients do not contain specific mutations related to acute exacerbation.
 PMID: 11680583       2001       Digestive diseases and sciences
Abstract: A 1896 precore stop codon mutant (G to A at nt 1896) coexisting with the wild sequence was found in both patients prior to seroconversion from HBeAg to anti-HBe.


  Reactivation of precore mutant hepatitis B virus in chemotherapy-treated patients.
 PMID: 11753968       2001       Cancer
Abstract: A point mutation from G to A at nt 1896 was detected in five of these six patients.
Abstract: BACKGROUND: A point mutation from G to A at nucleotide (nt) 1896 of the precore region of hepatitis B virus (HBV) DNA has been shown to be associated with fulminant and severe hepatitis.
Abstract: Prophylactic use of lamivudine is strongly recommended for patients who carry mutant HBV at precore region, especially at nt 1896 (G to A), before and during chemotherapy.



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