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 HBV mutation literature information.


  Initial load of hepatitis B virus (HBV), its changing profile, and precore/core promoter mutations correlate with the severity and outcome of acute HBV infection.
 PMID: 17380283       2007       Journal of gastroenterology
Abstract: In univariate analysis, seronegativity for hepatitis B envelope antigen (HBeAg) and mutations in both the precore (G1896A and/or G1899A) and core promoter (T1753A/C and/or T1754C/G and/or A1762T/G1764A) were associated with FH (odds ratio [OR], 5.60; P=0.0269 and OR, 52.0; P=0.0006; respectively).


  Influences on hepatitis B virus replication by a naturally occurring mutation in the core gene.
 PMID: 17498766       2007       Virology
Abstract: The clone belonged to genotype B with precore stop codon mutation (G1896A).


  Impact of viral genotypes and naturally occurring mutations on biological properties of hepatitis B virus.
 PMID: 17627632       2007       Hepatology research
Abstract: At the step of translation, a G1896A nonsense mutation in the precore region abolishes HBeAg expression.
Abstract: Subsequent studies by others established the role of polymorphism at nucleotide 1858, rather than genotype, as the determinant for the G1896A mutation.
Abstract: We first reportedthat the G1896A mutation rarely occurred in genotype A.


  Association between lamivudine sensitivity and the number of substitutions in the reverse transcriptase region of the hepatitis B virus polymerase.
 PMID: 17697019       2007       Journal of viral hepatitis
Abstract: Sequence analysis of the HBV genome revealed that point mutations in the precore region (G1896A) and enhancer I (A1287G/C) were observed more frequently in the good responder group than in the poor responder group (P = 0.002 and 0.019 respectively), and the number of substitutions in the reverse transcriptase domain of the polymerase was significantly higher in the good responders than in the poor responders (P = 0.026).


  Five subgenotypes of hepatitis B virus genotype B with distinct geographic and virological characteristics.
 PMID: 17825452       2007       Virus research
Abstract: In addition to the characteristics of HBV/B(1)-B(5) at some cis-acting elements, the precore stop-codon mutant (G1896A) was significantly different among HBV/B(1), HBV/B(2), and HBV/B(4) (70.3%, 31.7%, 53.0%, P=0.001), while no such mutation was found in HBV/B(3) and B(5).


  Hepatitis B virus genotype E detected in Brazil in an African patient who is a frequent traveler.
 PMID: 17934636       2007       Brazilian journal of medical and biological research
Abstract: The preC/C region showed G1896A and G1899A mutations but no mutations in the basal core promoter.


  Clinical significance of basal core promoter and precore mutations in chronic hepatitis B.
 PMID: 18265656       2007       Hepato-gastroenterology
Abstract: HBeAg-negative samples were associated with precore mutations (G1896A and G1899A).


  Hepatitis B virus genotyping, core promoter, and precore/core mutations among Afghan patients infected with hepatitis B: a preliminary report.
 PMID: 16419114       2006       Journal of medical virology
Abstract: In parallel, precore G1896A mutation was also determined by an amplification-created restriction site method.


  [Study of the quasispecies dynamics of serum hepatitis B virus in a patient with acute exacerbations of chronic hepatitis B].
 PMID: 16420761       2006       Zhonghua gan zang bing za zhi
Abstract: All dominant quasispecies, except the one during the second resolution, carried core P5T, L60V, S155T, and precore G1896A mutations.


  High prevalence and mapping of pre-S deletion in hepatitis B virus carriers with progressive liver diseases.
 PMID: 16618410       2006       Gastroenterology
Abstract: METHODS: The sequences of the pre-S region and the BCP (A1762T, G1764A) and PC (G1896A) mutations were determined in 46 HBV chronic carriers (CC) and 106 age-matched carriers with different stages of liver diseases, including 38 chronic hepatitis (CH), 18 cirrhosis (LC), and 50 hepatocellular carcinoma (HCC).



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