literature

HBV mutation literature information.

Complete genome analysis of hepatitis B virus in Qinghai-Tibet plateau: the geographical distribution, genetic diversity, and co-existence of HBsAg and anti-HBs antibodies.

PMID: 32532295 2020 Virology journal

Result: Other mutations, including stop codon mutation G1896A, were identically detected in CD1 and CD2 isolates.

Table: G1896A

In silico Analysis of Genetic Diversity of Human Hepatitis B Virus in Southeast Asia, Australia and New Zealand.

PMID: 32283837 2020 Viruses

Abstract: The three HBV variants identified most frequently were p.V5L, c.1896G>A and double mutation c.1762A>T/c.1764G>A, while genotypes B and C had the widest range of mutation types.

The genetic variability of hepatitis B virus subgenotype F1b precore/core gene is related to the outcome of the acute infection.

PMID: 31846615 2020 Virus research

Abstract: Mutations T1753C, A1762T, G1764A, C1766T, T1768A G1896A, G2092T and T2107C were associated with acute liver failure and progression to chronic hepatitis.

Virological Factors Associated With the Occurrence of Hepatitis B Virus (HBV) Reactivation in Patients With Resolved HBV Infection Analyzed Through Ultradeep Sequencing.

PMID: 31550370 2020 The Journal of infectious diseases

Abstract: The population of S3N amino acid substitution and nucleotide G1896A and G1899A mutations in each individual showed a similar percentage of occurrence.

Abstract: The prevalence of the S3N amino acid substitution in the envelope protein and mutations at positions G1896A and G1899A in the precore region were significantly higher in the HBVr compared with AHB.

Case Report: Application of hepatitis B virus (HBV) deep sequencing to distinguish between acute and chronic infection.

PMID: 33458253 2020 Wellcome open research

Conclusion: G1896A converts codon 28 from tryptophan (TGG) to a stop codon (TAG) and terminates the translation of the HBeAg precursor .

Conclusion: The most prevalent minority variant mutations in our HBV sequences were G1896A, G1899A and G1764A (precore/core and basal core promotor sequences respectively) ( Table 1).

Table: G1896A

Quadruple mutation GCAC1809-1812TTCT acts as a biomarker in healthy European HBV carriers.

PMID: 33055418 2020 JCI insight

Method: For control of the assays, a GTA

Result: The specificity of the blot was proven by using an additional genome containing the precore double mutation G1896A/G1899A, which was used as an additional HBeAg negative control, and by using an HBeAg positive WT genome as a positive control (Figure 3A).

Discussion: Interestingly, BCP double mutation was found in both HBeAg-positive and HBeAg-negative patients, underlining that this mutation does not completely abolish HBeAg, like, for example, the precore mutation G1896A, which converts TGG to the stop codon TAG.

Optimization of the algorithm diagnosis chronic hepatitis B markers in patients with newly diagnosed HIV infection.

PMID: 33245644 2020 Klinicheskaia laboratornaia diagnostika

Abstract: When analyzing the basal nucleus promoter, Precore and Core regions, 22.2% of patients with the double mutation A1762T / G1764A, 25% with the mutation G1896A were identified.

Molecular and serological characterization of hepatitis B vaccine breakthrough infections in serial samples from two plasma donors.

PMID: 30943997 2019 Virology journal

Discussion: Neither the precore stop codon mutation G1896A which abolishes HBeAg production or the basal core promoter mutations which cause reduced HBeAg production were found in any samples from either panel.

Naturally Occurring Mutations within HBV Surface Promoter II Sequences Affect Transcription Activity, HBsAg and HBV DNA Levels in HBeAg-Positive Chronic Hepatitis B Patients.

PMID: 30669266 2019 Viruses

Method: Furthermore, mutants C18T, G82A, A115C, G120A, A138G, and C189A in SPII were cloned into a plasmid pBlueBac4.5 1.2/PC (p1.2/PC) respectively, which contained a 1.2-fold length HBV genome of genotype C2 with a G1896A mutation in the preC region.

Analysis of fitness differences of hepatitis B virus genotypes D and F using a cotransfection assay.

PMID: 30417200 2019 Archives of virology

Abstract: Our results show that for the subgenotype (sgt) D1, which has an 8-nucleotide deletion (sgtD1del) and exhibits lower fitness, the levels of extracellular DNA and intracellular replicative intermediates were much lower than with sgtD1wt or sgtD1mut (G1896A), which had higher fitness.

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