literature

Quantification of complex precore mutations of hepatitis B virus by SimpleProbe real time PCR and dual melting analysis.

PMID: 21665530 2011 Journal of clinical virology

Introd

Introduction: However, about 9% HBeAg-positive patients had G1896A mutant as dominant species.

Method: Precore G1896A and G1899A quantification assay.

Hepatitis B virus genotype B with G1896A and A1762T/G1764A mutations is associated with hepatitis B related acute-on-chronic liver failure.

PMID: 21739444 2011 Journal of medical virology

Abstract: In conclusion, CHB patients with genotype B, G1896A, and A1762T/G1764A had a higher tendency to develop liver failure than patients with genotype C.

Abstract: In genotype B patients, the A1762T/G1764A, A1846T, and G1896A mutations were significantly more prevalent in patients with acute-on-chronic liver failure than CHB (50.7% vs.

Abstract: In multivariate analysis, the risk factors for acute-on-chronic liver failure were genotype B, A1762T/

PMID: 21785721 2011 Hepatitis research and treatment

Result: A1762T/G1764A double mutation existed in all clones, and G1896A existed in 4 clones obtained from all ti

Discussion: In the present study, all clones of the mother from three time points had double mutations of nucleotide A1762T/G1764A in basal core promoter (BCP), four of which were also coupled with G1896A.

Discussion: Other mutations such as C934A, C2351T/A2353T, C2444T, A1762T/G1764A, and G1896A were scattered in the whole genomes.

Emergence of the rtA181T/sW172* mutant increased the risk of hepatoma occurrence in patients with lamivudine-resistant chronic hepatitis B.

PMID: 21933446 2011 BMC cancer

Abstract: Virological factors including HBV-DNA level, genotype, precore G1896A, BCP A1762T/G1764A, rtM204I/V, rtA181T and pre-S internal deletion mutations as well as clinical variables including subsequent use of rescue drugs were submitted for outcome analysis.

Method: The methods to detect HBV basal core promoter (BCP) A1762T/G1764A mutations, precore stop codon G1896A mutation,

PMID: 21950207 2011 British journal of biomedical science

Abstract: The BCP/PreC mutations A1762T, G1764A, G1896A and C1766T were identified in 2.9-11.7% of subjects.

Hepatitis B virus genotype and basal core promoter/precore mutations are associated with hepatitis B-related acute-on-chronic liver failure without pre-existing liver cirrhosis.

PMID: 20070500 2010 Journal of viral hepatitis

Abstract: Single mutations including T1753V (C/A/G), A1762T, G1764A, G1896A and G1899A and triple mutations T1753V/A1762T/G1764A and A1762T/G1764A/C1766T (or T1768A

Introduction: A higher prevalence of the BCP double mutation A1762T/G1764A and the G1896A PC mutation have been reported in ALF than in acute hepatitis B patients.

Features and clinical implications of hepatitis B virus genotypes and mutations in basal core promoter/precore region in 507 Chinese patients with acute and chronic hepatitis B.

PMID: 20080060 2010 Journal of clinical virology

Abstract: Significantly lower prevalence of A1762T, G1764A, G1896A, and G1899A but higher prevalence of T1758C was found in AHB patients.

Distribution and hepatocellular carcinoma-related viral properties of hepatitis B virus genotypes in Mainland China: a community-based study.

PMID: 20160279 2010 Cancer epidemiology, biomarkers & prevention

Abstract: A1762T/G1764A, T1753V, C1653T, and G1896A, except PreS deletion, consecutively increased with increasing age.

Abstract: In contrast to G1896A, PreS deletion, T31C, T1753V, and A1762T/G1764A were more frequent in subgenotype C2 than in subgenotype B2.

Establishment of an HBsAg mixed titer performance panel and HBsAg working standard for quality control of HBsAg diagnostic kits in Korea.

PMID: 20347609 2010 Journal of clinical virology

Abstract: A G1896A and a T/I126S mutant are included in the positive samples.

Main mutations in the hepatitis B virus basic core promoter (A1762T/G1764A) before HBeAg loss are markers that identify patients who will require long-term treatment.

PMID: 20374224 2010 Alimentary pharmacology & therapeutics

Abstract: AIMS: To evaluate hepatitis B virus (HBV) genotype and the main mutations in the basic core promoter (BCP, A1762T/G1764A) and precore (G1896A) sequences as markers of persistent HBV-DNA after HBeAg loss.