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 HBV mutation literature information.


  Mutations in the hepatitis B virus precore/core gene and core promoter in patients with severe recurrent disease following liver transplantation.
 PMID: 8938164       1996       Hepatology (Baltimore, Md.)
Abstract: Previously, we reported that infection with HBV strains containing a mutation in the precore region (G-to-A at nucleotide 1896) was associated with severe recurrent disease posttransplantation.


  Semiquantitative assessment of pre-core stop-codon mutant and wildtype hepatitis B virus during the course of chronic hepatitis B using a new PCR-based assay.
 PMID: 8973525       1996       Archives of virology
Abstract: 1896 G-->A mutant HBV and to determine the ratio of mutant and wildtype HBV in patients' sera.
Abstract: 1896 G-->A mutant HBV could be determined semiquantitatively.
Abstract: 1896 G-->A mutant from wildtype HBV.


  Pathogenesis of chronic liver disease in patients with chronic hepatitis B virus infection without serum HBeAg.
 PMID: 9011456       1996       Digestive diseases and sciences
Abstract: Chronic hepatitis B in patients lacking hepatitis B e antigen has been attributed to a hepatitis B virus variant (G-to-A mutation at nucleotide 1896 in the precore region of the genome).


  The mechanism of natural occurrence of two closely linked HBV precore predominant mutations.
 PMID: 7645207       1995       Virology
Abstract: The preferential occurrence of the G to A mutation at nt 1896 and 1899, instead of at other nonpredominant positions, is likely to be a combined consequence of both selection and higher intrinsic mutation frequency at these positions.


  Precore mutant of hepatitis B virus in childhood fulminant hepatitis B: an infrequent association.
 PMID: 7706802       1995       The Journal of infectious diseases
Abstract: A precore mutation from G to A at nucleotide 1896 was found in 5 of 14 FHB patients and in 3 of 10 AHB patients.


  Detection of hepatitis B virus precore TAG mutant by an amplification-created restriction site method.
 PMID: 7798663       1995       The Journal of infectious diseases
Abstract: A new method for detecting the hepatitis B virus (HBV) precore 1896 G-->A mutation is described.
Abstract: This method of detecting HBV precore 1896 G-->A should be useful for evaluation and follow-up of patients and for prevalence studies.


  Nucleotide sequence analysis of precore and proximal core regions in patients with chronic hepatitis B treated with interferon.
 PMID: 7821093       1995       Digestive diseases and sciences
Abstract: Mutations that prevent HBeAg synthesis were found in three patients, all of whom had G-to-A substitution at nt 1896 and two of them were anti-HBe positive.


  Hepatitis B virus strains with mutations in the core promoter in patients with fulminant hepatitis.
 PMID: 7825758       1995       Annals of internal medicine
Abstract: RESULTS: A point mutation from G to A at nucleotide 1896 in the precore region was detected in 519 (98%) of 529 HBV DNA clones from 38 patients.


  Detection of hepatitis B precore mutants by the fluorescent linear polymerase chain reaction sequencing method.
 PMID: 7699256       1994       Journal of hepatology
Abstract: Precore variants were detected in one HBeAg positive and in all 20 anti-HBe positive patients: in 19 cases, G to A at position 1896, with or without the substitution G to A at position 1899, in two cases C to T substitution at position 1817 which also produces a stop codon (CAA to TAA), one accompanied by the mutation G to A at position 1896.
Abstract: These results indicate that the main cause of non-expression of HBeAg in chronic hepatitis B in our country is the substitution of G to A at nucleotide 1896, alone or accompanied by other variants.


  Different prevalence of precore mutants in five members of a hepatitis-B-virus-infected family: evidence for a precore variant type in an asymptomatic anti-HBs patient.
 PMID: 7890897       1994       Journal of hepatology
Abstract: A method for rapid screening of a large number of cloned polymerase chain reaction products was developed for the presence of the most frequent pre-C mutations (G to A substitution at nucleotide position 1896 and 1899).



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