[Results of a novel real-time PCR, sequence analysis, Inno-LiPA line probe assays in the detection of hepatitis B virus G1896A precore mutation in French blood donors].
Abstract: As HBV infected blood donors were more often asymptomatic carriers, we could speculate that the G1896A mutation may favour the asymptomatic state, supporting previous observations.
Abstract: Three methods were used to detect G1896A mutation: non-commercial real-time PCR (PCRTR , line probe assay (InnoLiPA HBV PreCore, INNOGENETICS( )) and direct sequencing of precore gene.
Characterization of hepatitis virus B isolated from a multi-drug refractory patient.
Abstract: RESULTS: HBV precore/core gene mutation increased significantly more in the inflammatory phase than in the tolerance phase (G1896A, 76.2% versus 4.8%; C1913A, 33.3% versus 0%; C2189A, 28.6% versus 4.8%; G2304A, 52.4% versus 14.3%) in study group (n = 21) but not the control group (n = 9).
Natural history of chronic hepatitis B REVEALed.
PMID: 21323729
2011
Journal of gastroenterology and hepatology
Abstract: A significant association with risk of cirrhosis and HCC was also observed for HBV genotype, precore G1896A mutant and basal core promoter A1762T/G1764A double mutant.
Precore and core promoter mutations of the hepatitis B virus gene in chronic genotype C-infected children.
PMID: 21468263
2011
Journal of Korean medical science
Abstract: The precore (G1896A) and core promoter (A1762T, G1764A) mutations of the hepatitis B virus gene are known to be associated with changes in immunologic phase or the progression to complicated liver disease in adults.
Introduction: Discussion: In the precore gene, the guanine-to-adenine mutation at nucleotide 1896 (G1896A) is the most prevalent.
Discussion: The precore mutation (G1896A) was less prevalent than CP mutations (i.e., 5% of ICP patients, 32.5% of HBeAg negative carriers, and 22.5% of ITP patients).
Geographical and ethnic distribution of the HBV C/D recombinant on the Qinghai-Tibet Plateau.
Abstract: The predominance of the premature pre-core stop mutation G1896A in patients with the HBV C/D recombinant may account for the higher prevalence of HBeAg in these patients.
Abstract: Virologically HBV/CD1 had a significantly lower frequency of G1896A than HBV/C2.
Full genome characterization of hepatitis B virus strains from blood donors in Iran.
Abstract: The molecular analysis of the individual genes revealed that the G1896A mutation was present in 86.2% of the strains and in 26 strains (29.9%) this mutation was accompanied by the G1899A mutation.
T1846 and A/G1913 are associated with acute on chronic liver failure in patients infected with hepatitis B virus genotypes B and C.
Abstract: The aim of the present study was to investigate whether there was correlation between A336C/A336T/T337C variations and spontaneous HBeAg loss METHODOLOGY/PRINCIPAL FINDINGS: A modified PCR-RFLP assay and ELISA were adopted to determine A336C/A336T/T337C variations and serum HBeAg levels in chronic hepatitis B patients without any antiviral therapy, respectively, whereas G1896A variation and HBV genotype were detected using Taqman-PCR assay.
Result: A336C/A336T/T337C variations correlated with G1896A
HBV mutation literature information.
PMID: 
2011
Pathologie-biologie
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