Abstract: CONCLUSIONS: Reactivation from occult HBV infection is characterized by low genetic heterogeneity, with the wild-type G1896 or G1896A variant prevalent.
Abstract: Prevalence of the G1896A variant in latently infected livers was determined among 44 healthy individuals that were HBsAg-negative but anti-HBc-positive.
Abstract: The G1896A variant was detected in 42.9% (6/14) of cases, including two cases with fatal liver failure.
Abstract: The G1896A variant was observed in the liver tissue of 11.4% (5/44) of individuals with occult HBV infection.
Abstract: The reactivated viruses in each case were almost exclusively the wild-type G1896 or PMID: 25040474
2014
Vox sanguinis
Abstract: Mutations in the S region (100%) were found especially in loop 1 of the major hydrophilic loop (MHL) at positions I110L, T114S, T126I and S113T, whereas mutations in the C region (65%) were within the basal core promoter region (position A1762T/G1764A) and precore region (position G1896A).
Hepatitis B virus genotype B and mutations in basal core promoter and pre-core/core genes associated with acute-on-chronic liver failure: a multicenter cross-sectional study in China.
Abstract: A multivariate analysis showed that factors such as HBV genotype B, age >=40 years and A1762T/G1764A, A1846T and G1896A mutations were independently associated with the development of HB-ACLF.
Abstract: CONCLUSION: Chronic HBV infection with genotype B, A1762T/G1764A, A1846T and G1896A mutations has a higher possibility to develop HB-ACLF.
Abstract: The A1762T/G1764A, A1846T and G1896A mutations were significantly m
S gene mutants occurrence among hepatitis B carriers in malaysia.
Abstract: Additionally, several mutations were found in the BCP region with the following incidence rate; C1653 T (8.6%), A1752 G (10.8%),1762 AGG--TGA 1764 (26.9%), C1766T(2.2%),T1768 A (10.8%), C1858 T (64.5%), G1896 A (25.8%).
Result: Another identified precore mutation was G1896A with the occurrence of 25.8%.
[Relationship between hepatitis B virus polymerase gene mutation patterns of rtM204I/V and pre-core/basal core promoter mutations].
Abstract: OBJECTIVE: To investigate the relationship between mutations of rtM204V/I (methionine to valine or isoleucine at position rt204 of reverse transcriptase domain) in the hepatitis B virus (HBV) polymerase gene and the G1896A and G1899A single mutations in the pre-eore (PC) region and the A1762T and G1764A double-mutations in the basal core promoter (BCP) region.
Abstract: Of the 1543 strains (54.2%) with PC-BCP mutations, seven mutation patterns of
Hepatitis B virus genotypes and mutations in the basal core promoter and pre-core/core in chronically infected patients in southern Brazil: a cross-sectional study of HBV genotypes and mutations in chronic carriers.
PMID: 25626648
2014
Revista da Sociedade Brasileira de Medicina Tropical
Abstract: Genotype D had a higher prevalence of the G1896A mutation and the presence of a thymine at position 1858.
Abstract: The comparison between HBeAg status and the G1896A stop codon mutation in patients with genotype D revealed a relationship between HBV G1896A precore mutants and genotype D and hepatitis B e antigen (HBeAg) seroconversion.
Hepatitis B virus core promoter mutations in patients with chronic hepatitis B and hepatocellular carcinoma in bucharest, romania.
Abstract: BCP A1762T, G1764A and PC G1896A were significantly associated with HCC-tissue HBV sequencing (75.3%) (P < 0.001).
Abstract: Basal core promoter (BCP) A1762T/G1764A and precore (PC) G1896A mutations were detected in these Romanian patients with chronic HBV infection.
Abstract: PC G1896A alone was detected in PMID: 24973814
2014
Journal of clinical virology
Abstract: In the 56 mother-child pairs with 1-15 year-old children acquired the infection from their mothers, the frequencies of HBV mutations including A1762T/G1764A and G1896A in genotype B2 or C2 increased consecutively with increasing age of children.
Abstract: These mutations including A1762T/G1764A in genotype C2 and G1896A in genotype B2 were more frequent in mothers than in children (P<0.001).
Novel point and combo-mutations in the genome of hepatitis B virus-genotype D: characterization and impact on liver disease progression to hepatocellular carcinoma.
Discussion: According to the previous studies in HBV genotype B, genotype C and few studies with genotype D, BCP_A1762T/G1764A, precore_G1896A, EnhII_C1653T, BCP_T1753V mutations and pre S2 deletions are frequently associated risk factors of HCC.
Discussion: Another precore mutation, T1858C, which makes a pair with G1896A to stabilize the viral encapsidation signal and enhance viral replication, was observed significantly associated with more aggressive
Prevalence of mutations in basal core promoter and precore region of hepatitis B virus in vaccinated and nonvaccinated individuals of the aboriginal Nicobarese tribe of Car Nicobar Island, India.
Abstract: Among the nonvaccinated subjects, 3 (4.5%) had an A1762T mutation, 8 (12.1%) had a G1764A mutation, 11 (16.7%) had a G1896A mutation and 4 (6.1%) had a G1899A mutation.
HBV mutation literature information.
PMID: 
2014
Journal of hepatology
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