Abstract: The aim of the present study was to investigate whether there was correlation between A336C/A336T/T337C variations and spontaneous HBeAg loss METHODOLOGY/PRINCIPAL FINDINGS: A modified PCR-RFLP assay and ELISA were adopted to determine A336C/A336T/T337C variations and serum HBeAg levels in chronic hepatitis B patients without any antiviral therapy, respectively, whereas G1896A variation and HBV genotype were detected using Taqman-PCR assay.
Result: A336C/A336T/T337C variations correlated with G1896A
Quantification of complex precore mutations of hepatitis B virus by SimpleProbe real time PCR and dual melting analysis.
Discussion: Compared with DNA sequencing, melting curve analysis has the advantage of distinguishing whether G1896A and G1899A are separate (single mutations) or in the same genome (double mutation).
Discussion: Quantification of HBV G1896A mutant was reported previously using a TaqMan probe.
Discussion: The probe matched with the G1896A sequence, being almost identical to our SPC2 probe except complementary to each other.
Discussion: This could cause significant underestimation of the amount of G1896A.
Discussion: This probe could be used to quantify the G1896A single mutation but not G1896A/G1899A because the amplification signals of the double mutation could not be separated
Differences in HBV Replication, APOBEC3 Family Expression, and Inflammatory Cytokine Levels Between Wild-Type HBV and Pre-core (G1896A) or Basal Core Promoter (A1762T/G1764A) Mutants.
Abstract: In conclusion, CHB patients with genotype B, G1896A, and A1762T/G1764A had a higher tendency to develop liver failure than patients with genotype C.
Abstract: In genotype B patients, the A1762T/G1764A, A1846T, and G1896A mutations were significantly more prevalent in patients with acute-on-chronic liver failure than CHB (50.7% vs.
Abstract: In multivariate analysis, the risk factors for acute-on-chronic liver failure were genotype B, A1762T/ PMID: 21785721
2011
Hepatitis research and treatment
Result: A1762T/G1764A double mutation existed in all clones, and G1896A existed in 4 clones obtained from all time points.
Discussion: In the present study, all clones of the mother from three time points had double mutations of nucleotide A1762T/G1764A in basal core promoter (BCP), four of which were also coupled with G1896A.
Discussion: Other mutations such as C934A, C2351T/A2353T, C2444T, A1762T/G1764A, and G1896A were scattered in the whol
Emergence of the rtA181T/sW172* mutant increased the risk of hepatoma occurrence in patients with lamivudine-resistant chronic hepatitis B.
Abstract: Virological factors including HBV-DNA level, genotype, precore G1896A, BCP A1762T/G1764A, rtM204I/V, rtA181T and pre-S internal deletion mutations as well as clinical variables including subsequent use of rescue drugs were submitted for outcome analysis.
Method: The methods to detect HBV basal core promoter (BCP) A1762T/G1764A mutations, precore stop codon G1896A mutation, PMID: 21950207
2011
British journal of biomedical science
Abstract: The BCP/PreC mutations A1762T, G1764A, G1896A and C1766T were identified in 2.9-11.7% of subjects.
Hepatitis B virus genotype and basal core promoter/precore mutations are associated with hepatitis B-related acute-on-chronic liver failure without pre-existing liver cirrhosis.
Abstract: Single mutations including T1753V (C/A/G), A1762T, G1764A, G1896A and G1899A and triple mutations T1753V/A1762T/G1764A and A1762T/G1764A/C1766T (or T1768A
Introduction: A higher prevalence of the BCP double mutation A1762T/G1764A and the G1896A PC mutation have been reported in ALF than in acute hepatitis B patients.
Features and clinical implications of hepatitis B virus genotypes and mutations in basal core promoter/precore region in 507 Chinese patients with acute and chronic hepatitis B.
HBV mutation literature information.
PMID: 
2011
Journal of medical virology
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