Abstract: Sixty-seven patients (82.7%) were HBeAg negative, and the prevalence of precore mutant isolates (G1896A) was higher in this group than in HBeAg-positive patients.
Abstract: The HBV PC (G1896A) mutation may play an important role in the clinical outcome of the disease by increasing the risk of progressive liver disease among Iranian patients infected with HBV.
Pre-core/basal-core promoter and reverse transcriptase mutations in chronic HBV infected-patients.
Abstract: For combined mutations, A1762T+G1764A (23.43% vs. 11.59 %, p<0.05) and G1896A+ G1899A (21.88% vs. 13.04%, p<0.05) were significantly more frequent in ACLF-HBV than CHB patients.
Abstract: In HBV pre-core/ BCP region, the point mutations T1753C (39.06% vs. 21.74%, p<0.01), A1762T (26.56% vs. 13.04%, p<0.05), G1764A (31.25% vs. 18.84%, p<0.01), G1896A (29.69% vs. 15.94%, p<0.05) and G1899 (23.44% vs. 10.14%, p<0.05) were significantly more frequent in the ACLFHBV than CHB patients.
Hepatitis B virus genotypes, precore mutations, and basal core promoter mutations in HBV-infected Chinese patients with persistently normal alanine aminotransferase and low serum HBV-DNA levels.
PMID: 22358356
2012
The Brazilian journal of infectious diseases
Abstract: The most common mutations were G1896A (23.6%), G1764A (9.0%), and A1762T (6.7%).
Genetic analysis of precore/core and partial pol genes in an unprecedented outbreak of fulminant hepatitis B in India.
Abstract: A1762T, G1764A basal core promoter (BCP) mutations, insertion of isoleucine after nt 1843, stop codon mutation G1896A, G1862T transversion plus seven other mutations in the core gene caused inhibition of HBeAg expression implicating them as circulating precore/BCP mutant virus.
Natural history of chronic hepatitis B: what exactly has REVEAL revealed?
Abstract: Genetic features including HBV genotype and basal core promoter A1762T/G1764A mutant, and precore G1896A mutant were documented as predictors of HCC risk.
Dynamics of hepatitis B virus quasispecies in association with nucleos(t)ide analogue treatment determined by ultra-deep sequencing.
Abstract: Four of eight (50%) chronic therapy-naive HBeAg-negative patients showed a relatively low prevalence of the G1896A pre-core (pre-C) mutant in the liver tissues, suggesting that other mutations were involved in their HBeAg seroconversion.
Abstract: Interestingly, liver tissues in 4 of 5 (80%) of the chronic NA-treated anti-HBe-positive cases had extremely low levels of the G1896A pre-C mutant (0.0%, 0.0%, 0.1%, and 1.1%), suggesting the high sensitivity of the G1896A pre-C mutant to NA.
Table: G1896A
Figure: (A) The relative proportion of the
HBV genotypes prevalence, precore and basal core mutants in Morocco.
PMID: 22579480
2012
Infection, genetics and evolution
Abstract: In 70 studied strains, HBV mutants were detected in 88.6% of cases; PC mutants were detected in (40%) of patients and 21.5% present a mixture of wild type and G1896A mutation.
Precore mutation of hepatitis B virus may contribute to hepatocellular carcinoma risk: evidence from an updated meta-analysis.
Abstract: Besides, the mutations like G1896A and BCP double mutation may be associated with the progression of the liver diseases.
Abstract: CONCLUSIONS: Precore mutation G1896A, G1899A, deletions in Pre-S region as well as the other commonly seen mutations correlated with the increased risk of HCC, especially in Asians and may predict the progression of the liver disease.
[Analysis of the complete hepatitis B virus genomes in a patient for repeated seroconversion to anti-HBe antibody due to co-infection with two virus clones].
PMID: 22686039
2012
Rinsho byori. The Japanese journal of clinical pathology
Abstract: In one HBe antibody-positive clone, a pre-core mutation associated with HBe antigen negativity (G1896A) was found.
Molecular analysis of hepatitis B virus associated with vaccine failure in infants and mothers: a case-control study in Thailand.
HBV mutation literature information.
PMID: 
2012
Journal of medical virology
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