Abstract: Incidences of point mutation T53C (preS1F53L), G1613A (polR841K), G1775A and A1762T + G1764A in the basal core promoter region, G1896A and G1899A in precore region and A2189C (coreI97L) in core region increased along with acute hepatitis B, chronic hepatitis B, and acute-on-chronic liv
Distinct evolution and predictive value of hepatitis B virus precore and basal core promoter mutations in interferon-induced hepatitis B e antigen seroconversion.
Abstract: UNLABELLED: Precore (PC) (G1896A) and basal core promoter (BCP) (A1762T/G1764A) mutations of the hepatitis B virus (HBV) genome often emerge in chronic hepatitis B (CHB) patients.
Effects of genomic changes in hepatitis B virus on postoperative recurrence and survival in patients with hepatocellular carcinoma.
Result: Patients with any genomic change in HBV (G1896A in precore region, A1762T/G1764A in BCP region, C1653T and T1753V in X region, or pre-S2 deletion) did not exhibit different survival periods from those without such changes (Table 3).
Result: The G1896A mutation in the PC region was detected in 51 % of patients with HBV-associated HCC.
Result: The presence of mutants such as G1896A in the precore region, A1762T
Molecular characterization of hepatitis B virus in liver disease patients and asymptomatic carriers of the virus in Sudan.
Abstract: Basic core promoter/precore region mutations, including the G1896A in 37% of HBeAg-negative individuals, could account for hepatitis B e antigen-negativity.
Result: A1762T/G1764A was found in 11 G1896A mutants and in one T1815C mutant.
Result: In 22/49 HBeAg-negative sera, the absence of HBeAg was as a result of missense mutations affecting the translation of the HBeAg precursor: 18 had the classical stop codon mutation G1896A (p< 0.05, when comparing isolates from HBeAg-negat
HBsAg, HBeAg and HBV DNA level changes and precore/basal core promoter mutations in the natural history of chronic hepatitis B in Indonesian patients.
Abstract: We studied the changes in hepatitis B surface antigen (HBsAg), hepatitis B 'e' antigen (HBeAg) and HBV DNA levels, considering the implications of HBV genotype, basal core promoter (BCP) A1762T/G1764A and precore G1896A mutations in CHB.
The Possible Role of TLR2 in Chronic Hepatitis B Patients with Precore Mutation.
Abstract: The G1896A pre-core mutation were detected in 29 (57%) which was significantly associated with higher concentration of serum TLR2 in comparison with patients without this mutation (4.8 +- 2.9 versus 3.4 +- 2.2 ng/mL, P = 0.03).|mgd
Introduction: In this study, the association of serum TLR2 with clinical findings in chronic hepatitis B patients especially in patients with G1896A stop codon mutation has been investigated.
Method: Precore G1896A Mutation Detection and Direct Sequencing.
Method: The Mann-Whitney U test was utilized to test equality of TLR2 and ALT between patients with G1896A precore mutation and patients without mutation.
High endemicity and low molecular diversity of hepatitis B virus infections in pregnant women in a rural district of North Cameroon.
Abstract: In the PC region, 83/228 patients (36.4%) harbored a G1896A mutant or mixed phenotype virus.
Discussion: Concerning the HBV heterogeneity in the PC region, the most frequently reported mutation is G1896A, which pairs with a T in nucleotide 1858.
Discussion: In Guinea, a similar G1896A mutation prevalence (21%) was described in blood donors infected with HBV/E.
Discussion: In our study, it was surprising to note the low prevalence of the G1896A mutation (21.4%) with the high percentage of the C1858T mutation (99.1%) detected in HBV/E, whereas these two point mutations are usually associated.
Discussion: Our results confirm those of previous reports indicating a G1896A<
Molecular characterisation of hepatitis B virus in the resident Chinese population in Panama City.
PMID: 23903967
2013
Memorias do Instituto Oswaldo Cruz
Result: The analysis of mutations in the Enh II, PC and BCP regions of the 10 samples revealed the following results: the mutation G1613A was identified in two samples (20%), two samples (20%) had the mutation pair A1762T/G1764A and one sample carried both G1896A and the A1762T/G1764A double mutation.
Discussion: The mutation pair A1762T/G1764A was found in three samples, with one sample concurrently showing the BCP mutation G1896A; this group of mutations abolished the secretion of HBeAg<
Association of Hepatitis B Virus Mutations of A1846T and C1913A/G With Acute-on-Chronic Liver Failure Development From Different Underlying Chronic Liver Diseases.
Abstract: In addition, there were no significant differences in mutations at T1753V, A1762T, G1764A, G1896A, and G1899A which were found between either CHB and ACLF-CHB or LC and ACLF-LC patients, suggesting no associations of these mutations with ACLF development.
Introduction: In comparison with CHB patients, liver cirrhosis (<
Table: G1896A
[Effect of PTPRD rs2279776 gene and interaction with hepatitis B virus mutations on the risk of hepatocellular carcinoma].
PMID: 24518026
2013
Zhonghua liu xing bing xue za zhi
Abstract: The interaction of rs2279776 GC genotype with G1896A could reduce the risk of HCC in HBV genotype B infected subjects and the interaction of CC genotype with A1652G significantly reduced the risk of HCC in HBV genotype C infected subjects.
HBV mutation literature information.
PMID: 
2013
Journal of medical virology
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