Introduction: In this study, the association of serum TLR2 with clinical findings in chronic hepatitis B patients especially in patients with G1896A stop codon mutation has been investigated.
Method: Precore G1896A Mutation Detection and Direct Sequencing.
Method: The Mann-Whitney U test was utilized to test equality of TLR2 and ALT between patients with G1896A precore mutation and patients without mutation.
Result: Clinical Significance of G1896A Precore Mutation and Serum TLR2.
Result: Demographic characteristics and frequency of the G1896A precore muta
High endemicity and low molecular diversity of hepatitis B virus infections in pregnant women in a rural district of North Cameroon.
Abstract: In the PC region, 83/228 patients (36.4%) harbored a G1896A mutant or mixed phenotype virus.
Method: In the PC region, two nucleotide changes were analyzed: the presence of a point mutation from G to A at nucleotide 1896 (G1896A), which signals the mutant PC phenotype; and the change C to T at position 1858, which defines the C1858T mutation.
Discussion: Concerning the HBV heterogeneity in the PC region, the most frequently reported mutation is G1896A, which pairs with a T in nucleotide 1858.
Discussion: In Guin
Association of Hepatitis B Virus Mutations of A1846T and C1913A/G With Acute-on-Chronic Liver Failure Development From Different Underlying Chronic Liver Diseases.
Abstract: In addition, there were no significant differences in mutations at T1753V, A1762T, G1764A, G1896A, and G1899A which were found between either CHB and ACLF-CHB or LC and ACLF-LC patients, suggesting no associations of these mutations with ACLF development.
Result: However there were no significant differences in previous reported hotspot mutations (T1753V, Table: G1896A
[Effect of PTPRD rs2279776 gene and interaction with hepatitis B virus mutations on the risk of hepatocellular carcinoma].
PMID: 24518026
2013
Zhonghua liu xing bing xue za zhi
Abstract: The interaction of rs2279776 GC genotype with G1896A could reduce the risk of HCC in HBV genotype B infected subjects and the interaction of CC genotype with A1652G significantly reduced the risk of HCC in HBV genotype C infected subjects.
HBsAg, HBeAg and HBV DNA level changes and precore/basal core promoter mutations in the natural history of chronic hepatitis B in Indonesian patients.
Abstract: We studied the changes in hepatitis B surface antigen (HBsAg), hepatitis B 'e' antigen (HBeAg) and HBV DNA levels, considering the implications of HBV genotype, basal core promoter (BCP) A1762T/G1764A and precore G1896A mutations in CHB.
Combination of preS deletions and A1762T/G1764A mutations in HBV subgenotype C2 increases the risk of developing HCC.
Abstract: Age (HR=1.068, P=0.020), G1896A mutation (HR=0.140, P=0.01) and A1846T mutation (HR=0.086, P=0.018) were associated with HBsAg seroclearance independently.
Abstract: Among dually-infected patients, genotype C was associated with a higher frequency of A1762T/G1764A mutation (P<0.001), but with lower HBV DNA (P<0.001) and a lower frequency of A1752T/G (P=0.008), C1799G (P<0.001) and G1896A mutation (P<0.001) than genotype B.
Abstract: Dually-infected patients had a higher prevalence of genotype C HBV (P=0.022) and a lower frequency of G1896A mutation (P=0.004) as compared with controls.
Mutational complex genotype of the hepatitis B virus X /precore regions as a novel predictive marker for hepatocellular carcinoma.
Abstract: CONCLUSIONS: Levels of G1896A and A1762T/G1764A mutants (of genotypes B and C) in the HBeAg-positive patients may predict the time of HBeAg seroconversion.
Abstract: Follow-up of 18 HBeAg-positive patients revealed that the mutant percentage may stay low and stable for many years, followed by a steady increase in the percentage of G1896A and/or A1762T/G1764A mutants, from <10% to 50-100%, within about 3 years prior to seroconversion.
Abstract: Mutant viruses carrying the precore G1896A and/or the basal core promoter (
HBV mutation literature information.
PMID: 
2013
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