Hepatitis B virus subgenotype C2- and B2-associated mutation patterns may be responsible for liver cirrhosis and hepatocellular carcinoma, respectively.
PMID: 23903686
2013
Brazilian journal of medical and biological research
Discussion: Multivariate analysis revealed that HBV subgenotype C2 infection and C2-associated mutation patterns (C1653T, T1753C, A1762T, and G1764A) contributed to the development of LC from CHB, and that B2-associated mutation patterns (C1810T, A1846T, G1862T, and G1896A) contributed to the development of HCC from LC.
Discussion: Our results showed that HBV subgenotype C2 and C2-associated mutation patterns (C1653T, T1753C, <
Molecular characterisation of hepatitis B virus in the resident Chinese population in Panama City.
PMID: 23903967
2013
Memorias do Instituto Oswaldo Cruz
Result: The analysis of mutations in the Enh II, PC and BCP regions of the 10 samples revealed the following results: the mutation G1613A was identified in two samples (20%), two samples (20%) had the mutation pair A1762T/G1764A and one sample carried both G1896A and the A1762T/G1764A double mutation.
Discussion: The mutation pair A1762T/G1764A was found in three samples, with one sample concurrently showing the BCP mutation G1896A; this group of mutations abolished the secretion of HBeAg<
HBsAg, HBeAg and HBV DNA level changes and precore/basal core promoter mutations in the natural history of chronic hepatitis B in Indonesian patients.
Abstract: We studied the changes in hepatitis B surface antigen (HBsAg), hepatitis B 'e' antigen (HBeAg) and HBV DNA levels, considering the implications of HBV genotype, basal core promoter (BCP) A1762T/G1764A and precore G1896A mutations in CHB.
Single-nucleotide polymorphism genotyping using a novel multiplexed electrochemical biosensor with nonfouling surface.
Abstract: A pre-core mutation in the hepatitis B virus (HBV) genome at G1896A and two adjacent polymorphisms in the human CYP2C19 genome at C680T and G681A were analysed.
[Effect of PTPRD rs2279776 gene and interaction with hepatitis B virus mutations on the risk of hepatocellular carcinoma].
PMID: 24518026
2013
Zhonghua liu xing bing xue za zhi
Abstract: The interaction of rs2279776 GC genotype with G1896A could reduce the risk of HCC in HBV genotype B infected subjects and the interaction of CC genotype with A1652G significantly reduced the risk of HCC in HBV genotype C infected subjects.
Association of Hepatitis B Virus Mutations of A1846T and C1913A/G With Acute-on-Chronic Liver Failure Development From Different Underlying Chronic Liver Diseases.
Abstract: In addition, there were no significant differences in mutations at T1753V, A1762T, G1764A, G1896A, and G1899A which were found between either CHB and ACLF-CHB or LC and ACLF-LC patients, suggesting no associations of these mutations with ACLF development.
Result: However there were no significant differences in previous reported hotspot mutations (T1753V, Table: G1896A
High endemicity and low molecular diversity of hepatitis B virus infections in pregnant women in a rural district of North Cameroon.
Abstract: In the PC region, 83/228 patients (36.4%) harbored a G1896A mutant or mixed phenotype virus.
Method: In the PC region, two nucleotide changes were analyzed: the presence of a point mutation from G to A at nucleotide 1896 (G1896A), which signals the mutant PC phenotype; and the change C to T at position 1858, which defines the C1858T mutation.
Discussion: Concerning the HBV heterogeneity in the PC region, the most frequently reported mutation is G1896A, which pairs with a T in nucleotide 1858.
Discussion: In Guin
Variability of the preC/C region of hepatitis B virus genotype A from a South African cohort predominantly infected with HIV.
Introduction: In this study, the association of serum TLR2 with clinical findings in chronic hepatitis B patients especially in patients with G1896A stop codon mutation has been investigated.
Method: Precore G1896A Mutation Detection and Direct Sequencing.
Method: The Mann-Whitney U test was utilized to test equality of TLR2 and ALT between patients with G1896A precore mutation and patients without mutation.
Result: Clinical Significance of G1896A Precore Mutation and Serum TLR2.
Result: Demographic characteristics and frequency of the G1896A precore muta
Hepatitis B virus in the State of Alagoas, Brazil: genotypes characterization and mutations of the precore and basal core promoter regions.
PMID: 24021712
2013
The Brazilian journal of infectious diseases
Abstract: The aims of this study were to investigate the genotypes of hepatitis B virus and to identify the precore G1896A and basal core promoter A1762T/G1764A mutations in HBsAg and anti-HBc-positive patients.
HBV mutation literature information.
PMID: 
2013
Brazilian journal of medical and biological research
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