Hepatitis B virus depicts a high degree of conservation during the immune-tolerant phase in familiarly transmitted chronic hepatitis B infection: deep-sequencing and phylogenetic analysis.
Abstract: By deep-sequencing, the quantitative analysis of the dynamics of basal core promoter (BCP) (A1762T, G1764A; A1766C; T1773C; 8-bp deletion; and other) and precore (G1896A) variants among HBV isolates from family members exhibited differences during the follow-up.
Molecular analysis of the interspousal transmission of hepatitis B virus in two Japanese patients who acquired fulminant hepatitis B after 50 and 49 years of marriage.
Abstract: Basic core promoter/precore region mutations, including the G1896A in 37% of HBeAg-negative individuals, could account for hepatitis B e antigen-negativity.
Result: A1762T/G1764A was found in 11 G1896A mutants and in one T1815C mutant.
Result: In 22/49 HBeAg-negative sera, the absence of HBeAg was as a result of missense mutations affecting the translation of the HBeAg precursor: 18 had the classical stop codon mutation G1896A (p< 0.05, when comparing isolates from HBeAg-negat
Effects of genomic changes in hepatitis B virus on postoperative recurrence and survival in patients with hepatocellular carcinoma.
Result: Patients with any genomic change in HBV (G1896A in precore region, A1762T/G1764A in BCP region, C1653T and T1753V in X region, or pre-S2 deletion) did not exhibit different survival periods from those without such changes (Table 3).
Result: The G1896A mutation in the PC region was detected in 51 % of patients with HBV-associated HCC.
Result: The presence of mutants such as G1896A in the precore region, A1762T
Distinct evolution and predictive value of hepatitis B virus precore and basal core promoter mutations in interferon-induced hepatitis B e antigen seroconversion.
Abstract: UNLABELLED: Precore (PC) (G1896A) and basal core promoter (BCP) (A1762T/G1764A) mutations of the hepatitis B virus (HBV) genome often emerge in chronic hepatitis B (CHB) patients.
A complete genomic analysis of hepatitis B virus isolated from 516 Chinese patients with different clinical manifestations.
Abstract: Incidences of point mutation T53C (preS1F53L), G1613A (polR841K), G1775A and A1762T + G1764A in the basal core promoter region, G1896A and G1899A in precore region and A2189C (coreI97L) in core region increased along with acute hepatitis B, chronic hepatitis B, and acute-on-chronic liv
Single-nucleotide polymorphism genotyping using a novel multiplexed electrochemical biosensor with nonfouling surface.
Abstract: A pre-core mutation in the hepatitis B virus (HBV) genome at G1896A and two adjacent polymorphisms in the human CYP2C19 genome at C680T and G681A were analysed.
Occult and Overt HBV Co-Infections Independently Predict Postoperative Prognosis in HCV-Associated Hepatocellular Carcinoma.
Discussion: Despite these inconvenient findings, it was found that the patients with occult HBVCI had a higher bilirubin level and a higher prevalence of precore stop codon G1896A mutation.
Discussion: Furthermore, precore G1896A mutation usually developed in patients suffering from repeated hepatitis flares during a long course of HBV infection.
Discussion: However, development of the precore G1896A mutation prevents the production of HBeAg, which provides a possible means to evade immune clearance and contributes to the persistence of occult PMID: 23599717
2013
Hepatitis monthly
Abstract: The predominant mutation of the precore region involves a G to A change at nucleotide1896, which creates a premature stop codon at codon 28.
Discussion: The G1896A mutation in the precore region has been found in patients with HBeAg negative chronic hepatitis B.
Associations of pri-miR-34b/c and pre-miR-196a2 polymorphisms and their multiplicative interactions with hepatitis B virus mutations with hepatocellular carcinoma risk.
Discussion: Pre-miR-196a2 rs11614913 TC genotype was significantly associated with increased frequencies of HCC-related HBV mutation G1896A (Table 3), furthermore, the interaction of this genotype with G1896A significantly increased HCC risk (Table 4); whereas the interaction of this genotype with A3120G/T, a strong HCC-related HBV mutation, significantly reduced the risk of HCC (Table 5).
Discussion: The effect of pre-m
Discussion: rs4938723 CC genotype and rs11614913 TC genotype might predispose the host to immune selection of T1674C/G, and G1896A, respectively.
HBV mutation literature information.
PMID: 
2014
Journal of viral hepatitis
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