Broad Range of Hepatitis B Virus (HBV) Patterns, Dual Circulation of Quasi-Subgenotype A3 and HBV/E and Heterogeneous HBV Mutations in HIV-Positive Patients in Gabon.
Result: The classical PC G1896A mutation was found in two (2/8, 14%) and four (4/6, 66.7%) HBV/A and HBV/E isolates, respectively (P = .31).
Table: G1896A
Potential Susceptibility Mutations in C Gene for Hepatitis B-Related Hepatocellular Carcinoma Identified by a Two-Stage Study in Qidong, China.
PMID: 27727182
2016
International journal of molecular sciences
Result: These include some well-studied mutations, such as pre-S2 start codon mutation, pre-S deletion, C1653T, T1753V, A1762T/G1764A, and G1896A mutations.
Severe de novo Hepatitis B Recovered from Late-Onset Liver Insufficiency with Prolonged Ascites and Hypoalbuminemia due to Hepatitis B Virus Genotype Bj with Precore Mutation.
PMID: 27920641
2016
Case reports in gastroenterology
Abstract: An immediate and sufficient suppression of virus replication with potent antiviral therapy is critical, particularly in patients infected with HBV precore mutation (G1896A) and/or Bj genotype, which may have a high viral replication and direct hepatocellular damage.
Abstract: Hepatitis B virus (HBV) isolated from the patient was of genotype Bj, with a precore mutation (G1896A) exhibiting an extremely high viral load at the onset of hepatitis.
Introduction: However, the prognosis of patients who develop hepatitis after chemotherapy including rituximab has shown to have high mortality, even when NA was administered; recently, the fulminant outcome of HBV reactivation associated with genotype Bj with precore<
Lower mutation frequency of BCP/precore regions in e antigen-negative chronic HBV-infected children instead of adults patients.
Abstract: The frequencies of these HBeAg seroconversion-related mutations were significantly lower in HBeAg-negative children with CHB than in HBeAg-negative adults with CHB, especially for the mutation G1896A (41.1% vs 91.7%, P<0.001), and the average number of BCP/precore region mutations in samples from HBeAg-negative child patients was also obviously lower than in HBeAg-negative adult patients(3.62+-3.03 vs 4.89+-2.09, P<0.001), suggesting less impact of mutations in the BCP/precore region on HBeAg se
Characterization of Full-Length Genomes of Hepatitis B Virus Quasispecies in Sera of Patients at Different Phases of Infection.
PMID: 25926495
2015
Journal of clinical microbiology
Abstract: A triple mutation (A1762T/G1764A/G1896A) was observed more frequently in genotype C than in genotype B.
Hepatitis B virus genotype distribution and genotype-specific BCP/preCore substitutions in acute and chronic infections in Argentina.
Discussion: Furthermore, despite the fact that all subgenotypes D have T1858, only subgenotypes D1 and D7 have a tendency to mutate G1896A.
Discussion: Given the fact that pC region overlaps the encapsidation signal, which is essential for efficient replication, those genotypes with T1858 would tend to mutate G1896A in order to increase stability of the stem loop in the encapsidation signal structure.
Discussion: In summary, those genotypes carrying 1858C seem to prevent G1896A mutation; however, T1858 polymorphism seems to be necessary but not sufficient to promote G1896A substitution.
Discussion: On the other hand, the high prevalence of mutations other than G1896A in the preCore region in subgenotype A2 indicates
Microarray-based genotyping and detection of drug-resistant HBV mutations from 620 Chinese patients with chronic HBV infection.
PMID: 25982306
2015
The Brazilian journal of infectious diseases
Abstract: Additionally, out of the 620 patient samples, 64.0% (397/620) were also detected with the precore stop-codon mutation (G1896A) by microarray assay.
Mutations of Basal core promoter and precore regions in hepatitis B virus genotypes B and C.
Correlation Between Hepatitis B G1896A Precore Mutations and HBeAg in Chronic HBV Patients.
PMID: 25825644
2015
Jundishapur journal of microbiology
Introduction: In this study, the G1896A precore mutation and its effect on HBeAg detection were investigated in chronic HBV patients, using polymerase chain reaction (PCR) and subsequent sequencing method, rather than the restriction fragment length polymorphism (RFLP), because of improving the sensitivity of the detection.
Introduction: The most common of these mutations is a guanine (G) to adenine (A) substitution at nucleotide1896, which prevents the production of HBeAg by introducing a premature stop codon into the open reading frame (ORF) of the PC.
Introduction: The predominant mutation involves a GtoA change at nucleotide1896 (A1896), which creates a premature stop
New point mutations in surface and core genes of hepatitis B virus associated with acute on chronic liver failure identified by complete genomic sequencing.
Result: As compared with non-ACLF cases, T216C, G285A, A1846T/G, G1896A, C1913A/G, A2159G/C, A2189T/C in genotype B and G285A, A1846T/G, G1896A, C1913A/G and A2159G/C in genotype C were significantly associated with an increased risk of ACLF(see Table 5).
Result: In ACLF group, the mutations at seven sites (T216C, G285A
HBV mutation literature information.
PMID: 
2016
PloS one
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