Result: Major substitutions that were detectable in the BCP/PC region of acute isolates included T1753C (2.7%), A1762T/G1764A (8.1%), A1814C (2.7%), G1896A (10.8%) and G1899A (5.4%).
Result: Notably, the frequency of pre-core substitutions (A1814C, G1896A, and G1899A) was relatively high in acute infection reaching to almost half of that present in chronic infection.
Discussion: Interestingly, the frequency of the mutation G1896A in the PMID: 26571304
2015
International journal of infectious diseases
Abstract: Two-thirds of HBeAg-negative subjects with high HBV DNA levels harboured BCP (A1762T/G1764A) and/or PC (G1896A) variants.
Hepatitis B virus genotype, mutations, human leukocyte antigen polymorphisms and their interactions in hepatocellular carcinoma: a multi-centre case-control study.
Discussion: In this study, the HBV mutations A1846T and G1896A, which have been reported to be associated with an increased risk of HCC by several studies, were not significantly associated with HCC.
Deep sequencing of hepatitis B virus basal core promoter and precore mutants in HBeAg-positive chronic hepatitis B patients.
Result: HBV BCP A1762T/G1764A and PC G1896A combinational patterns.
Result: No significant difference was observed for PC G1896A<
Result: besides classical A1762T/G1764A and G1896A mutants affecting codons 130/131 of X gene (K130M/V131I) and codon 28 of PC gene (W28stop), another 12 SNPs (nt.1719, nt.1726, nt.1727, nt.1730, nt.1752, nt.1753, nt.1768, nt.1800, nt.1803, nt.1804, nt.1805 and nt.1825) also caused amino acid changes.
Quantitative evaluation of hepatitis B virus mutations and hepatocellular carcinoma risk: a meta-analysis of prospective studies.
PMID: 26543337
2015
Chinese journal of cancer research
Abstract: No statistically significant association with HCC risk was observed for G1896A in the precore region (pooled-RR=0.77; 95% CI: 0.47-1.26).
Genetic variability of hepatitis B virus in Uruguay: D/F, A/F genotype recombinants.
Abstract: The following mutations were detected: a G1896A substitution, a 33-nucleotide deletion from position 2896 to 2928 in the Pre-S1 region involving Pre-S1 residues 3-13, a 33-nt deletion in the Pre-S1 region involving nt 2913-2945 and Pre-S1 residues 9-19.
Distribution of hepatitis B virus genotype and cancer predicting precore and basal core promoter mutations.
PMID: 26288490
2015
Medical journal, Armed Forces India
Abstract: The total Double mutations of BCP at A1762T/G1764A nucleotide positions, and PC mutation at G1896A nucleotide position were seen in 29.3% and 21.3%, respectively.
Abstract: Viral factors that may increase the risk for HCC development include HBV DNA level, genotypes, and naturally occurring mutations such as hepatitis B virus precore (PC) (G1896A) and basal core promoter (BCP) A1762T/G1764A double mutations.
Precore/basal core promoter mutants quantification throughout phases of hepatitis B virus infection by Simpleprobe.
PMID: 26074702
2015
World journal of gastroenterology
Abstract: In five HBeAg-negative cases, we detected double mutation G1896A/G1899A.
"Hepatitis B ""e"" antigen-mediated inhibition of HBV replication fitness and transcription efficiency in vitro."
Abstract: A mutation at nucleotide 1896 (G1896A) is the most common cause for the loss of HBeAg.
Abstract: Differences between the wild-type and the G1896A mutant in early steps of HBV replication including the synthesis of pre-genomic RNA and transcripts have not been investigated.
Abstract: In contrast to clinical data, cell culture studies report a high-replicating phenotype for the G1896A mutant.
Abstract: In sum, our findings highlight the role of HBeAg in regulating hepatitis B virus replication fitness and transcription efficiency and new insights on the early steps of replication in the G1896A mutant.
Abstract: Interestingly, trans-complementation of the G1896A mutant with HBeAg
[Characterization of basal core promoter/precore gene mutations in chronically infected patients with hepatitis B virus genotype D in Mersin Province, Turkey].
HBV mutation literature information.
PMID: 
2015
PloS one
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