Abstract: CONCLUSIONS: Reactivation from occult HBV infection is characterized by low genetic heterogeneity, with the wild-type G1896 or G1896A variant prevalent.
Abstract: Prevalence of the G1896A variant in latently infected livers was determined among 44 healthy individuals that were HBsAg-negative but anti-HBc-positive.
Abstract: The G1896A variant was detected in 42.9% (6/14) of cases, including two cases with fatal liver failure.
Abstract: The G1896A variant was observed in the liver tissue of 11.4% (5/44) of individuals with occult HBV infection.
Abstract: The reactivated viruses in each case were almost exclusively the wild-type G1896 or PMID: 25475418
2014
Mutation research. Reviews in mutation research
Abstract: We have described common mutations in the HBV genome (G1896A, rtM204V, rtM204I) which modulate the pathogenesis and carcinogenesis of the liver.
Molecular epidemiological study of hepatitis B virus genotypes in Southwest, China.
Abstract: 67.5% (56/83) of genotype C/D was Hepatitis B surface antigen (HBsAg) positive/Hepatitis B e antigen (HBeAg) positive/HBV DNA>=20,000 IU/ml, BCP A1762T/G1764A double mutation was frequent in genotype C and C/D, and G1896A was frequent in B and B/C.
Abstract: HBV infectious markers, HBV DNA and mutations in the basic core promoter (BCP) A1762T/G1764A and G1896A were analyzed.
Novel natural mutations in the hepatitis B virus reverse transcriptase domain associated with hepatocellular carcinoma.
Introduction: In addition, A2159G and A2189C in the core gene and G1896A and G1899A in the pre-C gene have also been reported to increase the risk of HCC.
Discussion: Another possibility to explain the rationality of A987G is that this mutation may be in linkage disequilibrium with other well-defined HCC-related mutations such as pre-S deletion, the BCP/EnhII region mutations C1653T, T1753A/G, C1762T
The Effect of HBV Genotype C on the Development of HCC Differs Between Wild-Type Viruses and Those With BCP Double Mutations (T(1762)A(1764)).
Introduction: Some mutations in HBV genome such as G1896A, C1653T, T1753V, the BCP double mutations (T1762A1764), and pre-S region deletions have been reported to be associated with HCC development.
Combinations of eight key mutations in the X/preC region and genomic activity of hepatitis B virus are associated with hepatocellular carcinoma.
Abstract: Accumulation of eight key mutations located in the X/preC regions of the hepatitis B virus (HBV) genome (G1613A, C1653T, T1753V, A1762T, G1764A, A1846T, G1896A and G1899A) is a risk marker for the development of hepatocellular carcinoma (HCC).
Abstract: In patients with >=6 mutations, the combination of [G1613A + C1653T + A1846T + G1896A] mutations was closely l
The impact of hepatitis B virus precore/core gene carboxyl terminal mutations on viral biosynthesis and the host immune response.
PMID: 24273041
2014
The Journal of infectious diseases
Abstract: RESULTS: The P135Q and G1896A were the most prevalent mutants before HBeAg seroconversion, acting as markers of HBeAg seroconversion (hazard ratios = 2.75 and 4.50; P = .01 and <.001, respectively).
Variability in the precore and core promoter region of the hepatitis B virus genome.
Abstract: The study confirmed that core promoter and precore mutations occur at key positions (A1762T, G1764A, G1896A, and G1899A), and that the proportions of strains with seroconvertion in patients differ between the four HBV genotypes.
Mutation profiling of the hepatitis B virus strains circulating in North Indian population.
Result: Precore promoter mutation (G1896A) was also observed in 46% (56/121) of HBV Genotype D and 25% (17/66) of HBV Genotype A patients.
Discussion: In the present study more than half of HBV isolates were HBeAg negative and often associated with Genotype D (G1896A) HBV infection (pre-core mutation).
Discussion: The presence of a cytosine at position 1858 precludes the G-to-A mutation at nt 1896, since this would destabilize the stem-loop structure of the RNA encapsidation signal.
Discussion: Therefore, in HBV genotype A, the G1896A mutation usually arises together with a C1858T nucleotide exchange.
Molecular characterization of HBV strains circulating among the treatment-naive HIV/HBV co-infected patients of eastern India.
Abstract: Moreover, the prevalence of G1896A was considerably high among the HBeAg negative HIV/HBV co-infected subjects compared to HBV mono-infection.
Abstract: The major mutations affecting HBeAg expression includes the A1762T/G1764A (13.6%), G1896A (22%) and G1862T mutation (33.9%) which was predominantly associated with HBV/A1.
Result: In 4 cases it occurred together with the T1753C mutation whereas in 5 cases the BCP mutations were accompanied by the G1896A precore mutation.|m
HBV mutation literature information.
PMID: 
2014
Journal of hepatology
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