The nucleotide changes within HBV core promoter/precore during the first 12weeks of nucleos(t)ide treatment might be associated with a better virological response.
PMID: 28088502
2017
Infection, genetics and evolution
Abstract: The mutation rates of A1762T/G1764A and G1896A were found to decrease from 46.2% (24/52) at baseline to 36.5% (19/52) at week 12 (P=0.426) and from 28.8% (15/52) to 21.2% (11/52) (P=0.497), respectively.
Differential regulation of hepatitis B virus core protein expression and genome replication by a small upstream open reading frame and naturally occurring mutations in the precore region.
Abstract: G1896A nonsense mutation promoted more efficient core protein expression than mutated precore ATG, while a +1 frameshift mutation was ineffective.
Result: As for the alphalM0 +36 series, the replication impact of the G1896A mutation was mild.
Result: Comparison of alphalM0, F (alphalM0 with mutated precore ATG), and alphal in the same blot indicates that G1896A/G1899A were more effective than mutated precore ATG in augmenting core protein expression, although ol+36 did not show higher core protein level than F+36.
Result: Considering that genotype G harbors two nonsense mutations in the PMID: 28325923
2017
Emerging microbes & infections
Result: With regard to the 'hot-spot' mutations in the HBV genome, G1896A in the preC region and A1762T/G1764A in the basic core promoter region were studied.
The association between hepatitis B mutants and hepatocellular carcinoma: A meta-analysis.
Discussion: Despite these limitations, we find that mutations G1896A, A1762T, G1764A, and A1762T/G1764A are associated with a higher risk of HCC.
Discussion: First, although the correlation between the mutation G1896A and HCC was statistically significant, the correlations between the risk of HCC and the mutation G1896A for genotypes B, C, and D were not.
Discussion: Mutation G1896A may suppress the expression of HBeAg by inducing a stop codon.
Discussion: This meta-analysis shows t
Chronic hepatitis B carriers with acute on chronic liver failure show increased HBV surface gene mutations, including immune escape variants.
Figure: The median incidence of A1762T/G1764A dual mutations in HBV Figure: b The incidence of G1896A mutation in HBV PC region was significantly more frequent in HBeAg negative hepatitis group than in both ACLF-CHB groups (****p < 0.0001) and immune active group (****p < 0.0001)
Figure: b The incidence of G1896A mutation in HBV PC region was significantly more frequent in HBeAg negative hepatitis group than in both ACLF-CHB groups (****p < 0.0001) and immune active group (****p < 0.0001).
Basal core promoter and precore mutations among hepatitis B virus circulating in Brazil and its association with severe forms of hepatic diseases.
PMID: 28902288
2017
Memorias do Instituto Oswaldo Cruz
Result: BCP and PC mutations and forms of chronic HBV infection - Among the 129 patients in whom the HBV PC region was analysed, a high frequency of HBV strains with G1896A mutation (53/129, 41%) was detected, alone or in G1896A/G1899A
Result: Among patients with HBV genotype D, the PC mutation G1896A was detected in 84.1% of the cases (53/63), while the G1862T mutation was detected in 92.3% of the subjects infected with HBV genotype A (36/39) (p < 0.01).
Result: Among the 58 sequences classified as genotype A in this study, only one exhibited the G1896A mutation.
Molecular characterization of hepatitis B virus in Vietnam.
Abstract: A G1896A mutation in the precore gene was present in 30.6% of genotype B isolates.
Result: A G1896A mutation in PC gene was present in 22.2% (30/135) of the isolates, including 30.6% (30/98) of the genotype B isolates compared to 0% of the C1 isolates (p < 0.000).
Table: G1896A
Discussion: Approximately one quarter of the genotype B patients had a G1896A mutation.
Prevalence and Characteristics of Precore Mutation in Iran and Its Correlation with Genotypes of Hepatitis B.
Discussion: Mutation of G1896A in PreC region shuts off the HBe Ag synthesis by introducing a stop codon.
Discussion: The G1896A mutation occurs when nucleotide 1858 is composed of the thymine-nitrogen base, which leads to better stabilization in lower stem.
Discussion: The frequency of the G1896A mutation was significantly higher in the HBe Ag negative patients in our study, which was compatible with results of previous studies.
Discussion: These findings were in agreement with the theory that the relation between G1896A precore mutatio
Discussion: also observed that PreC mutation (G1896A) is restricted to HBV strains with T1858 and hardly occurs in those with C1858.
Phenotypic and Genotypic Shifts in Hepatitis B Virus in Treatment-Naive Patients, Taiwan, 2008-2012.
Method: Three factors were significantly associated with HBeAg status: an increased prevalence of anti-HBe (p = 0.004) and increased prevalence of precore G1896A (p = 0.003) and G1899A (p = 0.019) mutations.
Hepatitis B virus sequencing and liver fibrosis evaluation in HIV/HBV co-infected Nigerians.
PMID: 28376292
2017
Tropical medicine & international health
5Result: The majority of the BCP/PC mutations were found in HBeAg-negative patients [BCP ""TA"": 12/30 eAg (-), 3/5 eAg (+); PC G1896A: 19/30 eAg (-), 1/5 eAg (+)], although analysis is limited by very low number of eAg+ sequences (n=5) and this was not statistically significant."
Result: Notably, all three HBeAg (+) patients with the double TA mutation, including one patient also with G1896A, experienced HBeAg seroconversion over the study period.
Result: Twenty patients (57%) had PC G1896A mutations and 12 (34%) had PC
HBV mutation literature information.
PMID: 
2017
Infection, genetics and evolution
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