Clinical, virologic and phylogenetic features of hepatitis B infection in Iranian patients.
PMID: 18803358
2008
World journal of gastroenterology
Abstract: The G1896A precore (PC) mutant was detected in 58.1% patients.
Virologic characteristics of hepatitis B virus in patients infected via maternal-fetal transmission.
PMID: 18837083
2008
World journal of gastroenterology
Abstract: The 1762T/1764A double mutation existed in all clones of the mother, 3 of them were also coupled with G1896A mutation, but none were found in the son.
HBV A1762T, G1764A mutations are a valuable biomarker for identifying a subset of male HBsAg carriers at extremely high risk of hepatocellular carcinoma: a prospective study.
PMID: 18844615
2008
The American journal of gastroenterology
Introduction: The common precore mutation (G1896A), mutations in enhancer II (C1653T) and the basal core promoter (T1753V and the double mutations, A1762T, G1764A), and deletions in the pre-S region have been reported to be associated with the development of HCC.
Molecular epidemiology of hepatitis B virus in Iran.
PMID: 18844687
2008
Clinical microbiology and infection
Abstract: HBsAg (17.2%), precore-G1896A (59.5%) and Basal core promoter (BCP) double mutations (49.2%), whereas no recombination was found.
LCR based quick detection of hotspot G1896A mutation in patients with different spectrum of hepatitis B.
PMID: 19178836
2008
Zhonghua yu fang yi xue za zhi [Chinese journal of preventive medicine]
Abstract: CONCLUSION: The point mutation in pre-core region G1896A of HBV dose not affect the positive rate of HBV DNA in breast milk and higher HBV DNA loads in serum of pregnant women might increase the risk of mother-infant transmission.
Abstract: OBJECTIVE: To investigate the relationship between pre-core G1896A point mutation of hepatitis B virus (HBV) and safety of breast feeding.
Abstract: PCR-solid phase hybridization was used to detect the point mutation in pre-core region G1896A of HBV from pregnant women, and HBV DNA loads in sera and breast milk were determined by fluorescence quantitative PCR (FQ-PCR).
Regulation of Toll-like receptor-2 expression in chronic hepatitis B by the precore protein.
Abstract: These results were confirmed in vitro using hepatic cell lines transduced with recombinant HBV baculovirus expressing wild-type HBV (HBeAg-positive), precore stop codon (G1896A) mutant HBV (HBeAg-negative).
Genotype and variations in core promoter and pre-core regions are related to progression of disease in HBV-infected patients from Northern Vietnam.
PMID: 17203204
2007
International journal of molecular medicine
Abstract: The rates of HBeAg seroconversion and G1896A for genotype B were significantly higher than those for genotype C (P<0.05).
Prevalence of hepatitis B virus genotype D in precore mutants among chronic liver disease patients from New Delhi, India.
PMID: 17211692
2007
Digestive diseases and sciences
Abstract: Our objective in this study was to genotype and detect the precore mutant with a point mutation from G to A at nucleotide 1896 using ligase chain reaction (LCR) and direct sequencing.
Initial load of hepatitis B virus (HBV), its changing profile, and precore/core promoter mutations correlate with the severity and outcome of acute HBV infection.
Abstract: In univariate analysis, seronegativity for hepatitis B envelope antigen (HBeAg) and mutations in both the precore (G1896A and/or G1899A) and core promoter (T1753A/C and/or T1754C/G and/or A1762T/G1764A) were associated with FH (odds ratio [OR], 5.60; P=0.0269 and OR, 52.0; P=0.0006; respectively).
Influences on hepatitis B virus replication by a naturally occurring mutation in the core gene.
HBV mutation literature information.
PMID: 
2008
World journal of gastroenterology
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