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 HBV mutation literature information.


  Broad Range of Hepatitis B Virus (HBV) Patterns, Dual Circulation of Quasi-Subgenotype A3 and HBV/E and Heterogeneous HBV Mutations in HIV-Positive Patients in Gabon.
 PMID: 26764909       2016       PloS one
Result: The classical PC G1896A mutation was found in two (2/8, 14%) and four (4/6, 66.7%) HBV/A and HBV/E isolates, respectively (P = .31).
Table: G1896A


  Potential Susceptibility Mutations in C Gene for Hepatitis B-Related Hepatocellular Carcinoma Identified by a Two-Stage Study in Qidong, China.
 PMID: 27727182       2016       International journal of molecular sciences
Result: These include some well-studied mutations, such as pre-S2 start codon mutation, pre-S deletion, C1653T, T1753V, A1762T/G1764A, and G1896A mutations.


  Severe de novo Hepatitis B Recovered from Late-Onset Liver Insufficiency with Prolonged Ascites and Hypoalbuminemia due to Hepatitis B Virus Genotype Bj with Precore Mutation.
 PMID: 27920641       2016       Case reports in gastroenterology
Abstract: An immediate and sufficient suppression of virus replication with potent antiviral therapy is critical, particularly in patients infected with HBV precore mutation (G1896A) and/or Bj genotype, which may have a high viral replication and direct hepatocellular damage.
Abstract: Hepatitis B virus (HBV) isolated from the patient was of genotype Bj, with a precore mutation (G1896A) exhibiting an extremely high viral load at the onset of hepatitis.
Introduction: However, the prognosis of patients who develop hepatitis after chemotherapy including rituximab has shown to have high mortality, even when NA was administered; recently, the fulminant outcome of HBV reactivation associated with genotype Bj with precore<


  Lower mutation frequency of BCP/precore regions in e antigen-negative chronic HBV-infected children instead of adults patients.
 PMID: 25822176       2015       PloS one
Discussion: Although the G1899A mutation only changes the glycine at codon 29 into aspartic acid and is always accompanied by the G1896A mutation, a previous study revealed that approximately 50% of the HBeAg negative variants contained this combined mutation.
Discussion: Deletions in core regions instead of the G1896A and A1762T/G1764A double mutation were observed in early seroconversion processes in a longitudinal study of infants (our own unpublished data), which also supports the idea that HBeAg seroconversion does not solely rely on BCP/precore mutations.
Discussion: In these six


  Characterization of Full-Length Genomes of Hepatitis B Virus Quasispecies in Sera of Patients at Different Phases of Infection.
 PMID: 25926495       2015       Journal of clinical microbiology
Abstract: A triple mutation (A1762T/G1764A/G1896A) was observed more frequently in genotype C than in genotype B.


  Hepatitis B virus genotype distribution and genotype-specific BCP/preCore substitutions in acute and chronic infections in Argentina.
 PMID: 25822666       2015       PloS one
Abstract: In anti-HBe positive chronic infections, sgF1b was more prone to have A1762T/G1764A mutation than sgA2, sgF4 and gD (75.0, 40.0, 33.3 and 31.8%, p<0.005), whereas in the pC region, gD and sgF4 were more likely to have G1896A than sgA2 and sgF1b (81.0, 72.7, 0.0 and 31.3%, p <0.001).
Abstract: The unexpected low frequency of the G1896A mutation in the sgF1b (despite carrying 1858T) prompted us to perform a further analysis in order to identify genotype-specific features that could justify the pattern mutations observed.
Result: In brief, those patients infected with sgF4 and gD mutated G1896A more frequently than A1762T/ PMID: 25982306       2015       The Brazilian journal of infectious diseases
Abstract: Additionally, out of the 620 patient samples, 64.0% (397/620) were also detected with the precore stop-codon mutation (G1896A) by microarray assay.


  Mutations of Basal core promoter and precore regions in hepatitis B virus genotypes B and C.
 PMID: 25741368       2015       Hepatitis monthly
Table: G1896A


  LCR based quick detection of hotspot G1896A mutation in patients with different spectrum of hepatitis B.
 PMID: 25825644       2015       Jundishapur journal of microbiology
Discussion: A higher rate (95.3%) of the G1896A mutation was also reported in the HBeAg-negative group.
Discussion: In agreement with our results, a study from Brazil showed that the G1896A PC mutation occurred in 36% of Brazilian patients with CHB, of which 58.6% were HBeAg-negative.
Discussion: The G1896A mutation in the PC region has been found to be the most


  New point mutations in surface and core genes of hepatitis B virus associated with acute on chronic liver failure identified by complete genomic sequencing.
 PMID: 25849554       2015       PloS one
Abstract: Multivariate analysis showed that T216C, G1896A, C1913A/G and A2159G/C were independent risk factors for ACLF.
Abstract: The results of Illumina sequencing showed that the mutations at 7 sites (T216C, G285A, A1846T, G1896A, C1913A/G, A2159G, and A2189C) of 12 ACLF patients were significantly higher than those of 12 controls.
Table: G1896A



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