Abstract: Our results show that for the subgenotype (sgt) D1, which has an 8-nucleotide deletion (sgtD1del) and exhibits lower fitness, the levels of extracellular DNA and intracellular replicative intermediates were much lower than with sgtD1wt or sgtD1mut (G1896A), which had higher fitness.
Hepatitis B virus in Mar del Plata, Argentina: Genomic characterization and evolutionary analysis of subgenotype F1b.
Abstract: A unique D3 presented the G1896A substitution at the preC (HBeAg negative phenotype).
Naturally Occurring Mutations within HBV Surface Promoter II Sequences Affect Transcription Activity, HBsAg and HBV DNA Levels in HBeAg-Positive Chronic Hepatitis B Patients.
Method: Furthermore, mutants C18T, G82A, A115C, G120A, A138G, and C189A in SPII were cloned into a plasmid pBlueBac4.5 1.2/PC (p1.2/PC) respectively, which contained a 1.2-fold length HBV genome of genotype C2 with a G1896A mutation in the preC region.
Molecular and serological characterization of hepatitis B vaccine breakthrough infections in serial samples from two plasma donors.
Discussion: Neither the precore stop codon mutation G1896A which abolishes HBeAg production or the basal core promoter mutations which cause reduced HBeAg production were found in any samples from either panel.
Nucleotide Substitutions in Hepatitis B Viruses Derived from Chronic HBV Patients.
PMID: 31308922
2019
Mediterranean journal of hematology and infectious diseases
Conclusion: Furthermore, the present data indicate a high rate of G1896A mutant in the PC region among Iranian CHB patients and a negative correlation between the emergence of A1762T/G1764A mutation and G1764T/C1766G mutant in the BCP region.
Introduction: The most common mutations involve G1896A in the
Result: A high proportion (61.0%, 16/26) of G1896A mutation occurred in the PC region.
Result: The G1899A mutation was found in 6 (23.0%) isolates and had concomitant G1896A change.
Next generation sequencing identifies baseline viral mutants associated with treatment response to pegylated interferon in HBeAg-positive chronic hepatitis B.
Abstract: No significant difference between groups was found regarding C1653T and G1896A mutants.
Locus 5p13.1 may be associated with the selection of cancer-related HBV core promoter mutations.
PMID: 31341412
2019
International journal of medical sciences
Introduction: The precore mutation (G1896A), mutations in enhancer II (C1653T) and the BCP (T1753V and the double mutations, A1762T, G1764A), and deletions in the pre-S region have been reported to be associated with the development of HCC.
Large-scale viral genome analysis identifies novel clinical associations between hepatitis B virus and chronically infected patients.
Abstract: Furthermore, we identified novel variants that either independently or in combination with precore mutation G1896A were associated with the transition from HBeAg positive to the negative phase of infection.
Discussion: Although G1896A had the most significant association with HBeAg status, we identified other variants that were important for understanding a patient's HBeAg status.
Discussion: It is worth mentioning that G1896A variants in HBV genotype A and some genotype C strains are rare due to genotype-specific constraints in the base-pairing of the pgRNA secondary structure and other mutations become solely responsible for the disruption of HBeAg production.
Discussion: While <
The Effect of the Hepatitis B Virus Surface Protein Truncated sC69( *) Mutation on Viral Infectivity and the Host Innate Immune Response.
Method: We cloned the sC69* mutant into plasmid pBB4.5 1.2/PC, which contained a 1.2-fold length HBV genome of genotype C with a G1896A mutation in the precore region.
Analysis of hepatitis B virus genotype and gene mutation in patients with advanced liver disease in East Kalimantan, Indonesia.
Abstract: The C1505A mutation in X region, T1753V and A1762T/G1764A mutations in the basal core promoter region and C1858T in precore (PC) region were frequent and only detected in patients with ALD (28.9, 40, 73.5 and 17.6%, respectively), whereas the G1896A mutation in the PC region was frequently detected in HBV carriers.
HBV mutation literature information.
PMID: 
2019
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