Abstract: The three HBV variants identified most frequently were p.V5L, c.1896G>A and double mutation c.1762A>T/c.1764G>A, while genotypes B and C had the widest range of mutation types.
The genetic variability of hepatitis B virus subgenotype F1b precore/core gene is related to the outcome of the acute infection.
Abstract: Mutations T1753C, A1762T, G1764A, C1766T, T1768A G1896A, G2092T and T2107C were associated with acute liver failure and progression to chronic hepatitis.
Virological Factors Associated With the Occurrence of Hepatitis B Virus (HBV) Reactivation in Patients With Resolved HBV Infection Analyzed Through Ultradeep Sequencing.
PMID: 31550370
2020
The Journal of infectious diseases
Abstract: The population of S3N amino acid substitution and nucleotide G1896A and G1899A mutations in each individual showed a similar percentage of occurrence.
Abstract: The prevalence of the S3N amino acid substitution in the envelope protein and mutations at positions G1896A and G1899A in the precore region were significantly higher in the HBVr compared with AHB.
Case Report: Application of hepatitis B virus (HBV) deep sequencing to distinguish between acute and chronic infection.
Conclusion: G1896A converts codon 28 from tryptophan (TGG) to a stop codon (TAG) and terminates the translation of the HBeAg precursor .
Conclusion: The most prevalent minority variant mutations in our HBV sequences were G1896A, G1899A and G1764A (precore/core and basal core promotor sequences respectively) ( Table 1).
Table: G1896A
Optimization of the algorithm diagnosis chronic hepatitis B markers in patients with newly diagnosed HIV infection.
Abstract: When analyzing the basal nucleus promoter, Precore and Core regions, 22.2% of patients with the double mutation A1762T / G1764A, 25% with the mutation G1896A were identified.
Quadruple mutation GCAC1809-1812TTCT acts as a biomarker in healthy European HBV carriers.
Method: For control of the assays, a GTA HBeAg-negative genome with precore double mutation G1896A/G1899A, a GTA HBeAg-positive genome.
Result: The specificity of the blot was proven by using an additional genome containing the precore double mutation G1896A/G1899A, which was used as an additional HBeAg negative control, and by using an HBeAg positive WT genome as a positive control (Figure 3A).
Discussion: Interestingly, BCP double mutation was found in both HBeAg-positive and HBeAg-negative patients, underlining that
Hepatitis B virus in Mar del Plata, Argentina: Genomic characterization and evolutionary analysis of subgenotype F1b.
Discussion: Neither the precore stop codon mutation G1896A which abolishes HBeAg production or the basal core promoter mutations which cause reduced HBeAg production were found in any samples from either panel.
Naturally Occurring Mutations within HBV Surface Promoter II Sequences Affect Transcription Activity, HBsAg and HBV DNA Levels in HBeAg-Positive Chronic Hepatitis B Patients.
Method: Furthermore, mutants C18T, G82A, A115C, G120A, A138G, and C189A in SPII were cloned into a plasmid pBlueBac4.5 1.2/PC (p1.2/PC) respectively, which contained a 1.2-fold length HBV genome of genotype C2 with a G1896A mutation in the preC region.
High possibility of hepatocarcinogenesis in HBV genotype C1 infected Cambodians is indicated by 340 HBV C1 full-genomes analysis from GenBank.
HBV mutation literature information.
PMID: 
2020
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