Introduction: We previously demonstrated that resolved HBV carriers with the G1896A variant (guanine to adenine mutant at nucleotide 1896) in the precore gene of the HBV genome might have an increased risk of HBV reactivation and fatal acute liver failure.
The mutation of hepatitis B virus and the prognosis of hepatocellular carcinoma after surgery: a pilot study.
PMID: 29628773
2018
Cancer management and research
Method: According to the sequencing outcome, HBV genotype and mutations (including A1752T/G, T1753C, G1757A, A1762T/G1764A, C1766T, T1768A, A1775G, C1799G, A1846T, T1858C, G1896A, G1898A, G1899A, and Pre S deletion) were confirmed by the BLAST analysis (http://blast.ncbi.nlm.nih.gov/Blast.cgi).
Result: According to different mutation regions, A1752T/G, T1753C,
LCR based quick detection of hotspot G1896A mutation in patients with different spectrum of hepatitis B.
1Abstract: Association of the pcG1896A mutation with time to undetectable HBV-DNA, hepatitis B ""e"" antigen (HBeAg) seroclearance (in HBeAg-positive patients), and hepatitis B surface antigen (HBsAg) seroclearance was evaluated using Cox proportional hazards regression."
Abstract: Baseline pcG1896A mutation was identified in 51 (59.3%) patients, who were more commonly HBeAg-negative (P < .001) and had basal core promotor A1762T/G1764A mutations (P < .001).
Abstract: Cumulative proportion of undetectable HBV-DNA was significantly higher in patients
LCR based quick detection of hotspot G1896A mutation in patients with different spectrum of hepatitis B.
PMID: 30505167
2018
Saudi journal of biological sciences
Abstract: It is of utmost importance to screen the G1896A precore mutation.
Abstract: LCR can be a suitable tool for screening of G1896A mutations.
Abstract: Patients were screened for the presence or absence of precore G1896A mutation by PCR-LCR.
Abstract: The exceptionally high prevalence of G1896A in FH and HCC demonstrates that the precore mutants are strongly associated with the progression of liver diseases in patients with HBeAg negative serology.
Abstract: The findings are also suggestive of sc
Clinical features and viral quasispecies characteristics associated with infection by the hepatitis B virus G145R immune escape mutant.
Result: With regard to the 'hot-spot' mutations in the HBV genome, G1896A in the preC region and A1762T/G1764A in the basic core promoter region were studied.
Differential regulation of hepatitis B virus core protein expression and genome replication by a small upstream open reading frame and naturally occurring mutations in the precore region.
Abstract: G1896A nonsense mutation promoted more efficient core protein expression than mutated precore ATG, while a +1 frameshift mutation was ineffective.
Result: As for the alphalM0 +36 series, the replication impact of the G1896A mutation was mild.
Result: Comparison of alphalM0, F (alphalM0 with mutated precore ATG), and alphal in the same blot indicates that G1896A/G1899A were more effective than mutated precore ATG in augmenting core protein expression, although ol+36 did not show higher core protein level than F+36.
Result: Considering that genotype G harbors two nonsense mutations in the PMID: 28088502
2017
Infection, genetics and evolution
Abstract: The mutation rates of A1762T/G1764A and G1896A were found to decrease from 46.2% (24/52) at baseline to 36.5% (19/52) at week 12 (P=0.426) and from 28.8% (15/52) to 21.2% (11/52) (P=0.497), respectively.
A novel hepatitis B virus subgenotype D10 circulating in Ethiopia.
Abstract: Difference in basal core promoter A1762T/G1764A mutations and precore G1896A mutation incidences was not significant between B/C recombinant and genotypes B or C virus, although the significance was there between genotypes B and C viruses.
HBV mutation literature information.
PMID: 
2018
Scientific reports
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