The nucleotide changes within HBV core promoter/precore during the first 12weeks of nucleos(t)ide treatment might be associated with a better virological response.
PMID: 28088502
2017
Infection, genetics and evolution
Abstract: The mutation rates of A1762T/G1764A and G1896A were found to decrease from 46.2% (24/52) at baseline to 36.5% (19/52) at week 12 (P=0.426) and from 28.8% (15/52) to 21.2% (11/52) (P=0.497), respectively.
Differential regulation of hepatitis B virus core protein expression and genome replication by a small upstream open reading frame and naturally occurring mutations in the precore region.
Abstract: G1896A nonsense mutation promoted more efficient core protein expression than mutated precore ATG, while a +1 frameshift mutation was ineffective.
Result: As for the alphalM0 +36 series, the replication impact of the G1896A mutation was mild.
Result: Comparison of alphalM0, F (alphalM0 with mutated precore ATG), and alphal in the same blot indicates that G1896A/G1899A were more effective than mutated precore ATG in augmenting core protein expression, although ol+36 did not show higher core protein level than F+36.
Result: Considering that genotype G harbors two nonsense mutations in the PMID: 28325923
2017
Emerging microbes & infections
Result: With regard to the 'hot-spot' mutations in the HBV genome, G1896A in the preC region and A1762T/G1764A in the basic core promoter region were studied.
The association between hepatitis B mutants and hepatocellular carcinoma: A meta-analysis.
Discussion: Despite these limitations, we find that mutations G1896A, A1762T, G1764A, and A1762T/G1764A are associated with a higher risk of HCC.
Discussion: First, although the correlation between the mutation G1896A and HCC was statistically significant, the correlations between the risk of HCC and the mutation G1896A for genotypes B, C, and D were not.
Discussion: Mutation G1896A may suppress the expression of HBeAg by inducing a stop codon.
Discussion: This meta-analysis shows t
Chronic hepatitis B carriers with acute on chronic liver failure show increased HBV surface gene mutations, including immune escape variants.
Conclusion: Interestingly, the G1896A and A1762T/G1764A mutations, although associated with fulminant hepatitis B development in other studies, were found at low frequency in Result: Higher incidence of A1762T/G1764A and G1896A mutations in HBV BCP/PC region in HBeAg negative hepatitis B patients.
Result: Similarly, the incidence of classic G1896A mutation in HBV precore region was significantly higher in HBeAg negative hepatitis group (80%) than that in both ACLF-CHB groups (0%, ****p < 0.0001) and immune active group (0%, ****p < 0.0001.
Basal core promoter and precore mutations among hepatitis B virus circulating in Brazil and its association with severe forms of hepatic diseases.
PMID: 28902288
2017
Memorias do Instituto Oswaldo Cruz
Result: BCP and PC mutations and forms of chronic HBV infection - Among the 129 patients in whom the HBV PC region was analysed, a high frequency of HBV strains with G1896A mutation (53/129, 41%) was detected, alone or in Result: Among patients with HBV genotype D, the PC mutation G1896A was detected in 84.1% of the cases (53/63), while the G1862T mutation was detected in 92.3% of the subjects infected with HBV genotype A (36/39) (p < 0.01).
Result: Among the 58 sequences classified as genotype A in this study, only one exhibited the G1896A mutation.
Table: G1896A
Molecular characterization of hepatitis B virus in Vietnam.
Abstract: A G1896A mutation in the precore gene was present in 30.6% of genotype B isolates.
Result: A G1896A mutation in PC gene was present in 22.2% (30/135) of the isolates, including 30.6% (30/98) of the genotype B isolates compared to 0% of the C1 isolates (p < 0.000).
Table: G1896A
Discussion: Approximately one quarter of the genotype B patients had a G1896A mutation.
Prevalence and Characteristics of Precore Mutation in Iran and Its Correlation with Genotypes of Hepatitis B.
Conclusion: Additional findings of our study were compatible with previous studies, which claimed that Iranian HBV viruses belong to genotype D and indicated significant association of the preC G1896A mutation with this genotype of HBV.
Intr
Introduction: G1896A mutation is most commonly associated with genotypes D, E, and B of HBV and is rare in other genotypes of HBV.
Introduction: The G1896A precore mutation leads to a conversion of codon 28 from TGG (tryptophan) to a premature stop codon TAG.
Result: Precore (G1896A) mutation was found in 34.1% (62 samples) of the study population, which produced two fragments of 261 and 34 bp in length, which were observable by electrophoresis (Figures 1, 2).
Phenotypic and Genotypic Shifts in Hepatitis B Virus in Treatment-Naive Patients, Taiwan, 2008-2012.
Method: Three factors were significantly associated with HBeAg status: an increased prevalence of anti-HBe (p = 0.004) and increased prevalence of precore G1896A (p = 0.003) and G1899A (p = 0.019) mutations.
Hepatitis B virus sequencing and liver fibrosis evaluation in HIV/HBV co-infected Nigerians.
PMID: 28376292
2017
Tropical medicine & international health
8Discussion: We found a high frequency of the ""TA"" mutation, (15/35, 43%) and G1896A mutation (20/35, 57%); mutations in these regions affect the production of HBeAg."
Result: Notably, all three HBeAg (+) patients with the double TA mutation, including one patient also with G1896A, experienced HBeAg seroconversion over the stud
Discussion: In the precore region, the G1896A mutation creates a stop codon in the precore gene abolishing HBeAg expression.
Discussion: The TA mutation frequency in this study was higher than that observed in other studies from Western Africa, although the frequency of G1896A was similar.
HBV mutation literature information.
PMID: 
2017
Infection, genetics and evolution
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