Abstract: In each case, similar mutations (G to A) in nucleotide 1896 of the preC region were found, together with additional mutations in the preC promoter.
Abstract: Patients who are chronic carriers of the HBV and who have a G to A mutation at nucleotide 1896 in the precore region may develop more severe liver disease, possibly because of rapid selection and enhanced replication ability of the mutant strain.
Sequence variations of precore/core and precore promoter regions of hepatitis B virus in patients with or without viral reactivation during cytotoxic chemotherapy.
Abstract: A G-to-A mutation at nt 1896 in the preC/C region (HBeAg negative/ anti-HBe positive) has been associated with more severe liver disease than that caused by wild type virus.
Polymorphism of precore region of hepatitis B virus DNA among patients with chronic HBV infection in Turkey.
Abstract: Seven of 47 HBeAg-positive patients (15%) and 29 of 34 HBeAg-negative patients (85%) had precore stop codon mutations (G to A change at nucleotide 1896).
[Dynamic changes of basal core promoter and pre-core mutants of hepatitis B virus in patients with chronic hepatitis B virus infection].
PMID: 12759956
1999
Zhonghua shi yan he lin chuang bing du xue za zhi
Abstract: Using two mis-matched primers to amplify BCP and pre-c gene fragments, in combination with restricted fragment length polymorphism assay, we studied the presence of these two mutants(nt 1762A-->T, 1764G-->A and nt1896G-->A) in 105 serum samples.
Association of mutations in the core promoter and precore region of hepatitis virus with fulminant and severe acute hepatitis in Japan.
PMID: 9870800
1998
Journal of gastroenterology and hepatology
Abstract: The presence of HBV mutants was examined by using a point mutation assay to detect a G to A transition at position 1896 in the precore region and an A to T transition at position 1762 and a G to A transition at position 1764 in the core promoter region.
Nucleic acid sequence analysis of the precore region of hepatitis B virus from sera of southern African black adult carriers of the virus.
Abstract: The presence of C instead of T in position 1858 precludes the G-to-A mutation at 1896 because the coexistence of these two mutations would destabilize the stem-loop structure of the RNA encapsidation signal, a finding confirmed by our observation that the CCC polymorphism and the 1896 mutation were mutually exclusive.
Genotype F prevails in HBV infected patients of hispanic origin in Central America and may carry the precore stop mutant.
Abstract: Since the three published precore sequences of genotype F strains have a C1858, which is known to prevent the precore stop mutation from G to A at position 1896, the precore and part of the core genes were sequenced from 19 anti-HBe positive sera with HBV DNA, 17 with genotype F and 2 with genotype A.
Detection of hepatitis B surface gene mutation in carrier children with or without immunoprophylaxis at birth.
PMID: 9237708
1997
The Journal of infectious diseases
Abstract: A precore mutant (G to A) at nucleotide 1896 was detected in sera from 11 carriers without vaccination.
Hepatitis B virus carriers without precore mutations in hepatitis B e antigen-negative stage show more severe liver damage.
Abstract: The G-->A mutation at nucleotide 1896 may mediate viral escape by creating a TAG stop codon in the precore region, thus preventing HBeAg production.
Rare pre-core stop-codon mutant nt. 1897 predominates over wide-spread mutant nt. 1896 in an unusual course of chronic hepatitis B.
Abstract: Direct sequencing of polymerase chain reaction (PCR) products derived from consecutive sera showed a rare pre-core stop-codon mutation at nucleotide (nt.) 1897 G --> A with an accompanying mutation nt. 1857 C --> T as well as a stop-codon mutation nt. 1896 G --> A.
HBV mutation literature information.
PMID: 
2000
Journal of medical virology
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