Abstract: In the HCC patients, T1938C and A2051C mutations in the core region had accumulated significantly with A1762T/G1764A mutations in the basal core promoter (BCP) region and G1896A mutation in the precore (PC) region.
High possibility of hepatocarcinogenesis in HBV genotype C1 infected Cambodians is indicated by 340 HBV C1 full-genomes analysis from GenBank.
Fulminant hepatitis B virus (HBV) infection in an infant following mother-to-child transmission of an e-minus HBV mutant: Time to relook at HBV prophylaxis in South African infants.
Abstract: Genetic analysis of virus from mother and infant showed that both had the G1896A mutation in the preC/C gene, which truncates hepatitis e antigen (HBeAg) during translation, causing an HBeAg-negative phenotype.
BCP/PC mutation prevalence and their association with HBV replication in HIV/HBV co-infected patients.
Abstract: A1762T, G1764A and G1896A mutations were common mutations identified in the BCP/PC region.
Abstract: However, the prevalence of the G1896A mutation was significantly high among the HBeAg negative HIV/HBV co-infected patients, and may be associated with high HBV replication.
Virological and Clinical Characteristics of Hepatitis B Virus Genotype A.
Abstract: Regarding virological factors, the G1896A precore mutation is rarely observed in genotype A as it would disrupt an essential stem-loop structure in the epsilon signal essential for pregenomic RNA packaging.
Human hepatocytes apoptosis induced by replication of hepatitis B virus subgenotypes F1b and F4: Role of basal core promoter and preCore mutations.
Abstract: The BCPdm (A1762T/G1764A) and preCore (G1896A) mutants induced higher levels of apoptosis than the wt virus.
A new hepatitis B virus e antigen-negative strain gene used as a reference sequence in an animal model.
PMID: 29339154
2018
Biochemical and biophysical research communications
Abstract: The G1896A variant resulted in a premature stop codon and abolished HBeAg expression.
Abstract: The main four point variants including A1762T, G1764A, G1896A, and G1899A were detected in the full-length genome.
Abstract: The strain will increase viral replication and infection for mutations A1762T and G1764A in the basal core promoter region, and mutations G1896A and G1899A in the pre-core region.
Analysis of HBV basal core promoter/precore gene variability in patients with HBV drug resistance and HIV co-infection in Northwest Ethiopia.
Abstract: However, HBV mono-infected blood donors and CLD patients who had no any drug resistance gene variants developed comparable G1862T (60.6% vs. 65.1%) and G1896A (24.2% vs. 11.6%) PC gene mutations.
Abstract: RESULTS: Among the major mutant variants detected, double BCP mutations (A1762T/G1764A) (25.9%), Kozak sequences mutations (nt1809-1812) (51.7%) and the classical PC mutations such as A1814C/C1816T (15.4%), G1896A (25.2%) and G1862T (44.8%) were predominant mutant variants.
Table: G1896A
Figure: Prevalence comparison of th
Clinical implication and viral mutation in basal core promoter/pre-core of hepatitis B virus C/D recombinant.
Abstract: The clonal frequencies of A1762T, G1764A, G1896A and A1846T were lower in patients with C/D than C2.
Abstract: but a lower frequency of G1896A stop mutation (33.6 vs. 76.5%, p < 0.001) was observed in patients with the C/D recombinant than in patients with genotype C2.
The Correlation Between Hepatitis B Virus Precore/Core Mutations and the Progression of Severe Liver Disease.
PMID: 30406036
2018
Frontiers in cellular and infection microbiology
Introduction: One of the most common precore mutations reported thus far is a G1896A, which prevents HBeAg production through the replacement of a tryptophan residue at amino acid position 28 with a premature stop codon (Tong et al.,).
Introduction: Similarly, the role of the precore mutation G1896A and the basal core promoter double mutation A1762T/G1764A in the progression of HBV-related liver diseases has been intensively studied (Kim et al.,).
Discussion: One of the most common precore mutations, detected in more than 50% of individuals with chronic hepat
HBV mutation literature information.
PMID: 
2019
Hepatology (Baltimore, Md.)
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