Sequence variations of precore/core and precore promoter regions of hepatitis B virus in patients with or without viral reactivation during cytotoxic chemotherapy.
Abstract: A G-to-A mutation at nt 1896 in the preC/C region (HBeAg negative/ anti-HBe positive) has been associated with more severe liver disease than that caused by wild type virus.
Polymorphism of precore region of hepatitis B virus DNA among patients with chronic HBV infection in Turkey.
Abstract: Seven of 47 HBeAg-positive patients (15%) and 29 of 34 HBeAg-negative patients (85%) had precore stop codon mutations (G to A change at nucleotide 1896).
[Dynamic changes of basal core promoter and pre-core mutants of hepatitis B virus in patients with chronic hepatitis B virus infection].
PMID: 12759956
1999
Zhonghua shi yan he lin chuang bing du xue za zhi
Abstract: Using two mis-matched primers to amplify BCP and pre-c gene fragments, in combination with restricted fragment length polymorphism assay, we studied the presence of these two mutants(nt 1762A-->T, 1764G-->A and nt1896G-->A) in 105 serum samples.
Association of mutations in the core promoter and precore region of hepatitis virus with fulminant and severe acute hepatitis in Japan.
PMID: 9870800
1998
Journal of gastroenterology and hepatology
Abstract: The presence of HBV mutants was examined by using a point mutation assay to detect a G to A transition at position 1896 in the precore region and an A to T transition at position 1762 and a G to A transition at position 1764 in the core promoter region.
Nucleic acid sequence analysis of the precore region of hepatitis B virus from sera of southern African black adult carriers of the virus.
Abstract: The presence of C instead of T in position 1858 precludes the G-to-A mutation at 1896 because the coexistence of these two mutations would destabilize the stem-loop structure of the RNA encapsidation signal, a finding confirmed by our observation that the CCC polymorphism and the 1896 mutation were mutually exclusive.
Genotype F prevails in HBV infected patients of hispanic origin in Central America and may carry the precore stop mutant.
Abstract: Since the three published precore sequences of genotype F strains have a C1858, which is known to prevent the precore stop mutation from G to A at position 1896, the precore and part of the core genes were sequenced from 19 anti-HBe positive sera with HBV DNA, 17 with genotype F and 2 with genotype A.
Detection of hepatitis B surface gene mutation in carrier children with or without immunoprophylaxis at birth.
PMID: 9237708
1997
The Journal of infectious diseases
Abstract: A precore mutant (G to A) at nucleotide 1896 was detected in sera from 11 carriers without vaccination.
Mutations in the hepatitis B virus precore/core gene and core promoter in patients with severe recurrent disease following liver transplantation.
Abstract: Previously, we reported that infection with HBV strains containing a mutation in the precore region (G-to-A at nucleotide 1896) was associated with severe recurrent disease posttransplantation.
Semiquantitative assessment of pre-core stop-codon mutant and wildtype hepatitis B virus during the course of chronic hepatitis B using a new PCR-based assay.
Abstract: 1896 G-->A mutant HBV and to determine the ratio of mutant and wildtype HBV in patients' sera.
Abstract: 1896 G-->A mutant HBV could be determined semiquantitatively.
Abstract: 1896 G-->A mutant from wildtype HBV.
Pathogenesis of chronic liver disease in patients with chronic hepatitis B virus infection without serum HBeAg.
PMID: 9011456
1996
Digestive diseases and sciences
Abstract: Chronic hepatitis B in patients lacking hepatitis B e antigen has been attributed to a hepatitis B virus variant (G-to-A mutation at nucleotide 1896 in the precore region of the genome).
HBV mutation literature information.
PMID: 
2000
Journal of viral hepatitis
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