Abstract: G1862T mutation was observed in the two HBV/A1 patients, resulting in the pre-core amino acid substitution with a switch from valine (Val) to phenylalanine (Phe).
Expression of wild-type or G1862T mutant HBe antigen of subgenotype A1 of hepatitis B virus and the unfolded protein response in Huh7 cells.
Abstract: G1862T was detected in 18 samples, 15 (83%) of them belonged to genotype A (subgenotype HBV/A1), 3 (17%) to genotype D.
Abstract: CONCLUSION: In our community, G1862T mutation was predominantly found in HBV/A1 isolates irrespective of HBeAg status.
Abstract: OBJECTIVE: To study the prevalence of G1862T mutation in hepatitis B virus (HBV) isolates among Eastern Indian patients and its relationship with genotypes, HBeAg status and disease manifestation.
Abstract: The mean viral load was lower in patients with G1862T mutation.
Abstract: These findings indicate that the G1862T mutation is probably a part of the natural variability of HBV/A1.
Basal core promoter, precore region mutations of HBV and their association with e antigen, genotype, and severity of liver disease in patients with chronic hepatitis B in India.
1Abstract: A naturally occurring G1862T mutation upstream of the core AUG affects the bulge of the epsilon signal and generates a ""forbidden"" residue at the -3 position of the signal peptide cleavage site."
Abstract: All these mutations antagonized the G1862T mutation on core protein expression.
Abstract: Cotransfection of the G1862T mutant with a replication-deficient HBV genome that provides core protein in trans also restored genome replication.
Mechanism of HBV genome variability and replication of HBV mutants.
Abstract: We found point mutations upstream of the precore ATG codon of genotype Aa suppressed HBeAg expression, while the G1862T mutation in the precore region greatly impaired viral replication.
Epidemiological and sequence differences between two subtypes (Ae and Aa) of hepatitis B virus genotype A.
PMID: 15039524
2004
The Journal of general virology
Abstract: In the pregenome encapsidation (epsilon) signal, a point mutation from G to A or T at nt 1862 was detected in 16 of the 19 (84 %) HBV/Aa isolates but not in any of the 20 HBV/Ae isolates, which may affect virus replication and translation of hepatitis B e antigen.
[The prevalence of hepatitis B virus precore mutant isolated from asymptomatic carriers in Guangxi].
PMID: 12667359
2002
Zhonghua liu xing bing xue za zhi
Abstract: Among samples with stopped mutation, 4 samples had mutation at nt1846 (A-->T), 2 samples at nt1862 (G-->T).
Expression of wild-type or G1862T mutant HBe antigen of subgenotype A1 of hepatitis B virus and the unfolded protein response in Huh7 cells.
PMID: 12185284
2002
The Journal of general virology
Abstract: The G-->T substitution at position 1862 leads to an amino acid change in codon 17 of the precore protein of the virus, which is part of a signal peptidase recognition motif.
Abstract: The prevalence of a G1862T variant of hepatitis B virus (HBV) has been investigated in patients with fulminant hepatitis and chronic liver disease, using primer mismatch amplification, followed by restriction fragment length polymorphism analysis.
HBV mutation literature information.
PMID: 
2009
Journal of the National Cancer Institute
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