Result: Pre-C genomic changes were found in three samples: G1862T in sample 2C, and mixed populations of stop codon G1896A mutant and wild-type virus (W28*W) in samples 3C and 6C.
Table: G1862T
Analysis of HBV basal core promoter/precore gene variability in patients with HBV drug resistance and HIV co-infection in Northwest Ethiopia.
Abstract: However, HBV mono-infected blood donors and CLD patients who had no any drug resistance gene variants developed comparable G1862T (60.6% vs. 65.1%) and G1896A (24.2% vs. 11.6%) PC gene mutations.
Abstract: RESULTS: Among the major mutant variants detected, double BCP mutations (A1762T/G1764A) (25.9%), Kozak sequences mutations (nt1809-1812) (51.7%) and the classical PC mutations such as A1814C/C1816T (15.4%), G1896A (25.2%) and G1862T (44.8%) were predominant mutant variants.
Method: During sequences analysis, much emphasis was given for the detection of mutations affec
Chronic hepatitis B carriers with acute on chronic liver failure show increased HBV surface gene mutations, including immune escape variants.
Introduction: In addition, mutations such as T1753 V (genotype A, C or G), T1754S (genotype C or G), G1862 T, T1961 V, C1962D (A, G or T), and A2339G were more frequently found in fulminant hepatitis.
Basal core promoter and precore mutations among hepatitis B virus circulating in Brazil and its association with severe forms of hepatic diseases.
PMID: 28902288
2017
Memorias do Instituto Oswaldo Cruz
Result: Among patients with HBV genotype D, the PC mutation G1896A was detected in 84.1% of the cases (53/63), while the G1862T mutation was detected in 92.3% of the subjects infected with HBV genotype A (36/39) (p < 0.01).
Result: HBV with G1862T and G1896A mutations, alone or in double mutation patterns, were the most frequent (31% and 44.2%, respectively).
Result: The G1862T mutation was previously described in association with HBV genotype A, particularly with sub-genotype A1.
Table: G1862T
Expression of wild-type or G1862T mutant HBe antigen of subgenotype A1 of hepatitis B virus and the unfolded protein response in Huh7 cells.
PMID: 28678685
2017
The Journal of general virology
Abstract: Cells transfected with the G1862T subgenotype A1 plasmid showed decreased expression of intracellular HBcAg and of nuclear preC/C/HBeAg and extracellular HBeAg, when compared to cells transfected with its wild-type counterpart as a result of the accumulation of the mutant protein in the endoplasmic reticulum (ER) and ER-Golgi intermediate compartment (ERGIC) .
Abstract: Huh7 cells were transfected with subgenotype A1 replication-competent plasmids, with and without G1862T.
Abstract: Increase in ER stress can result in liver damage, which has been shown to be a contributing factor to hepatocarcinogenesis and may explain why G1862T is frequently
Associations between hepatitis B virus basal core promoter/pre-core region mutations and the risk of acute-on-chronic liver failure: a meta-analysis.
Method: We used Stata software (version 12.0; Stata Corp, College Station, TX) to conduct the analysis and to calculate the ACLF summary estimates for the HBV genotype, HBeAg status and T1753V, A1762T, G1764A, A1762T/G1764A, C1766T, T1768A, A1846T, G1862T, G1896A, G1899A and A1762T/G1764A/G1896A mutations for ACLF patients.
Result:
Novel point and combo-mutations in the genome of hepatitis B virus-genotype D: characterization and impact on liver disease progression to hepatocellular carcinoma.
Abstract: Beyond the classical mutations in basal core promoter (BCP) (A1762T/G1764A) and precore (G1862T), persistence of progressively accumulated mutations in enhancer-I, surface, HBx and core were showed significant association to liver disease progression.
Result: Other two precore mutations G1862T and G1896A, which were frequently found in HBeAg negative patients, were noted exclusively in the advanced stages such as PMID: 24587360
2014
PloS one
Abstract: The major mutations affecting HBeAg expression includes the A1762T/G1764A (13.6%), G1896A (22%) and G1862T mutation (33.9%) which was predominantly associated with HBV/A1.
Result: Furthermore, the G1862T mutation was found in 33.9% (20/59) of the study subjects.
Discussion: A previous study also demonstrated that G1862T mutation was appreciably related to HBV/A1 rather than HBV/A2.
Discussion: Moreover, all the HBV/A isolates of this present study were associated with the G1862T, irrespective of HBeAg status.
Discussion: The G1862T mutation is known for affecting the expression of
Hepatitis B virus genotypes and mutations in the basal core promoter and pre-core/core in chronically infected patients in southern Brazil: a cross-sectional study of HBV genotypes and mutations in chronic carriers.
PMID: 25626648
2014
Revista da Sociedade Brasileira de Medicina Tropical
Abstract: Genotype A was associated with a higher prevalence of the G1862T mutation and the presence of a cytosine at position 1858.
Hepatitis B virus subgenotype C2- and B2-associated mutation patterns may be responsible for liver cirrhosis and hepatocellular carcinoma, respectively.
PMID: 23903686
2013
Brazilian journal of medical and biological research
Abstract: Four patterns (C1810T, A1846T, G1862T, and G1896A) were significantly associated with HCC compared with LC.
Abstract: Multivariate regression analyses showed that HBV subgenotype C2 and C2-associated mutation patterns (C1653T, T1753C, A1762T, and G1764A) were independent risk factors for LC when CHB was the control, and that B2-associated mutation patterns (C1810T, A1846T, G1862T,
HBV mutation literature information.
PMID: 
2020
PloS one
Browser Board
Co-occurred Entities
Filtrator
ViMRT