literature

HBV mutation literature information.

Frequency and clinical significance of core promoter and precore region mutations in Tunisian patients infected chronically with hepatitis B.

PMID: 22997074 2012 Journal of medical virology

Abstract: G1896A (74.8%), G1764A/T/C (71.5%), G1899A (54.4%) and T1678C (52%) were the most common.

Abstract: High DNA levels were associated with G1899A or G1764T/C-C1766G-C1799G and advanced liver disease with mutations at positions 1762, 1764 and/or 1899 alone or in double or triple mutations.

Variability in the precore and core promoter regions of HBV strains in Morocco: characterization and impact on liver disease progression.

PMID: 22905181 2012 PloS one

Result: In the BCP, G1764A was the most frequent (72/186, 38.7%), followed by A1762T (59/186, 31.7%), T1753V (28.5%), A1757G (21.5%), C1766G (48/186, 26%), C1766T (41/186, 22%), G1764T (35/186, 18.8%) and T1768A (29/186, 15.6%).

Result: The mutations T1636G, A1757G and G1764T/C1766G were exclusively found in genotype D strains.

Table: G1764T

HBV genotypes prevalence, precore and basal core mutants in Morocco.

PMID: 22579480 2012 Infection, genetics and evolution

Abstract: BCP mutants were observed in 65.7% of cases, 22.9% were found to have the T1762/1764A double mutation, 18.6% had A1762/1764T mutation and 22.9% of patients showed the A1762T/G1764A double mutation with either A1762T/G1764T mutation.

Full genome characterization of hepatitis B virus strains from blood donors in Iran.

PMID: 21503905 2011 Journal of medical virology

Abstract: The double mutations A1762T/G1764A and G1764T/C1766G were found in 20.7% and 24.1% of the strains, respectively.

Association of core promoter mutations with viral breakthrough in chronic hepatitis B patients on long-term lamivudine therapy.

PMID: 16928212 2006 Journal of gastroenterology and hepatology

Abstract: Core promoter mutations were seen in five of eight (62.5%) and in six of nine (66.6%); classic double mutations (A1762T/G1764A) of core promoter region were detected in two and three patients and novel double mutations of core promoter (G1764T/C1766G) in one patient each of group Ia and Ib patients, respectively.

Hepatitis B virus genotyping, core promoter, and precore/core mutations among Afghan patients infected with hepatitis B: a preliminary report.

PMID: 16419114 2006 Journal of medical virology

Abstract: Three isolates presented single mutation in the BCP dual mutation region, whereas two showed a novel G1764T mutation.

Hepatitis B virus core promoter mutations in children with multiple anti-HBe/HBeAg reactivations result in enhanced promoter activity.

PMID: 10534721 1999 Journal of medical virology

Abstract: In both patients, rare mutations were found in the BCP at nucleotides 1764(G-->T)/1766(C-->G) and 1766(C-->T)/1768(T-->A) in case 1 and 2, respectively.

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