literature

HBV mutation literature information.

Chronic hepatitis B carriers with acute on chronic liver failure show increased HBV surface gene mutations, including immune escape variants.

PMID: 29065883 2017 Virology journal

Conclusion: Interestingly, the G1896A and A1762T/G1764A mutations, although associated with fulminant hepatitis B development in other studies, were found at low frequency in ACLF patients compared to non-ACLF/HBeAg negative hepatitis CHB patients.

Figure: a The incidence of A1762T/G1764A dual mutations was significantly higher in HBeAg negative hepatitis group than in both HBeAg positive (****p < 0.0001) and HBeAg negative ACLF-CHB groups (****p < 0.0001) and immun

Patients with Coexistence of Circulating Hepatitis B Surface Antigen and Its Antibody May Have a Strong Predisposition to Virus Reactivation During Immunosuppressive Therapy: A Hypothesis.

PMID: 29248936 2017 Medical science monitor

Abstract: DNA sequencing analysis of the HBV genome revealed triple mutations (A1762T, G1764A, and T1753V) in the BCP region, which could further enhance the ability of HBV replication.

Abstract: Recent studies have shown that the uncommon serological pattern of coexistent circulating HBV surface antigen (HBsAg) and its antibody (anti-HBs) was associated with double mutations (A1762T/G1764A) in the basal core promoter (BCP) region of the HBV genome, which is critical for HBV replication.

Introduction: Coexistence of circulating HBsAg and anti-

Analyses of the Genetic Diversities and Mutations of the Hepatitis B Virus Genome BCP/Pre C Region.

PMID: 30702819 2017 Bing du xue bao

Abstract: Other mutations in descending order by mutation rate were a: A1762T/G1764A combined mutation (90. 48%); G1756C/T1803A/A(1757 ~ 1765)/A (1824 ~ 1832) combined mutation (80. 95%); T1753C/A1762T/ G1764A combined mutation (57. 14%); A1762T/G1764A/G1896A combined mutation (42. 86%); G1756C/_(1757~176.5) combined mutation,(28. 57%); T1753C/A1762T/G1764A/G1896A combined mutation (23. 81%).

Associations between serum HBX quasispecies and their integration in hepatocellular carcinoma.

PMID: 31966550 2017 International journal of clinical and experimental pathology

Abstract: In these, the HBX-integrated groups had significantly higher mutation frequencies at C1497T, A1630G, G1721A, A1762T/G1764A and A1774G.

Hepatitis B virus mutations, expression quantitative trait loci for PTPN12, and their interactions in hepatocellular carcinoma.

PMID: 27075395 2016 Cancer medicine

Result: Of those 19 hotspot mutations, C1653T, T1674C/G, A1703G, G1719T, T1727A/G, T1753C, A1762T, G1764A, G1799C, G1899A, G1915A/C, and C1969T were significantly associated with an increased risk of HCC, whereas C1673T, A1726C, C1730G, and A1752G were significantly associated with a reduced risk of

PMID: 26389515 2016 Hepatology (Baltimore, Md.)

Abstract: HBeAg-negative hepatitis subjects carried more A1762T/G1764A, C2063A, and A2131C HBV gene mutations than those without HBeAg-negative hepatitis.

Hepatitis B virus basal core promoter/precore mutants and association with liver cirrhosis in children with chronic hepatitis B virus infection.

PMID: 26577140 2016 Clinical microbiology and infection

Abstract: Among all the patients with genotype C viruses, the patients with LC had higher prevalence of C1653T, A1762T/G1764A and G1896A mutation frequency, higher hepatitis B e antigen (HBeAg) -negative rates, lower viral load, lower elevated alanine aminotransferase and lower anti-HBe positive rates than CHB patients.

Abstract: Patients with HBV genotype C viruses, high viral load and C1653T, A1762T/G1764A, G1896A mutant viruses, were more susceptible to developing

PMID: 26764909 2016 PloS one

Method: Finally, A1762T/G1764A mutations in BCP region and T1858C, G1862C andG1896A mutations in PC region were analyzed.

Result: One HBV/A strain (1/8, 12.5%) had BCP mutations whereas three (3/6, 50%) HBV/E strains showed the A1762T and G1764A double mutation (P = .35) (Table 2).

Table: G1764A

Differences in HBV Replication, APOBEC3 Family Expression, and Inflammatory Cytokine Levels Between Wild-Type HBV and Pre-core (G1896A) or Basal Core Promoter (A1762T/G1764A) Mutants.

PMID: 26848866 2016 Oncotarget

Table: G1764A

Figure: HCC occurrence between BCP A1762T/

Figure: BCP A1762T/G1764A dual mutations in HBV genotype B and C from chronic HBV infection patients, including HCC.

Complete genome analysis of hepatitis B virus in human immunodeficiency virus infected and uninfected South Africans.

PMID: 26890489 2016 Journal of medical virology

Abstract: The double (A1762T/G1764A) and triple (T1753C/A1762T/G1764A) mutations in the Basal core promoter were identified in four and two sequences, respectively.

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