Nucleotide Substitutions in Hepatitis B Viruses Derived from Chronic HBV Patients.
PMID: 31308922
2019
Mediterranean journal of hematology and infectious diseases
Conclusion: Furthermore, the present data indicate a high rate of G1896A mutant in the PC region among Iranian CHB patients and a negative correlation between the emergence of A1762T/G1764A mutation and G1764T/C1766G mutant in the BCP region.
Result:
Result: A1762T and G1764A were frequently detected together in 23.0% (6/26) of the isolates.
Result: However, none of the patients with A1762T/G1764A mutation carried the G1764T/C1766G mutant (Table 2).
Nearly half of Ultrio plus NAT non-discriminated reactive blood donors were identified as occult HBV infection in South China.
Abstract: The C1505A mutation in X region, T1753V and A1762T/G1764A mutations in the basal core promoter region and C1858T in precore (PC) region were frequent and only detected in patients with ALD (28.9, 40, 73.5 and 17.6%, respectively), whereas the G1896A mutation in the PC region was frequently detected in HBV carriers.
A substitution in the pre-S1 promoter region is associated with the viral regulation of hepatitis B virus.
Introduction: Double mutations, A1762T and G1764A, in the basic core promoter region result in decreased HBeAg expression and enhanced viral genome replication; these mutations are frequently found in HBeAg-negative chronic hepatitis patients.
Discussion: The A1762T and G1764A mutations in the basic core promoter region are associated with an increased risk of HCC in genotype C patients.
HBx-K130M/V131I Promotes Liver Cancer in Transgenic Mice via AKT/FOXO1 Signaling Pathway and Arachidonic Acid Metabolism.
Discussion: Taken together, these results provide a potential mechanism whereby HBV encoding X_K130M/V131I (BCP_A1762T/G1764A) may contribute to the high rate of HCC observed clinically in patient cohorts containing these mutations.
Discussion: The X_K130M/V131I amino acid changes are encoded by nucleotide changes at BCP_A1762T/G1764A, which also result in a decrease in PC/C mRNA and subsequent HBeAg expression.
Naturally Occurring Mutations within HBV Surface Promoter II Sequences Affect Transcription Activity, HBsAg and HBV DNA Levels in HBeAg-Positive Chronic Hepatitis B Patients.
Introduction: For instance, it was found that A1762T/G1764A were novel mutations within CP and could lead to decreased HBeAg expression but enhanced viral replication, which correlated with liver disease severity.
Discussion: Whether single-site mutations may have such a significant effect on activity, we refer to the effects of the A1762T/G1764A mutation in HBV.
Hepatitis B virus in Mar del Plata, Argentina: Genomic characterization and evolutionary analysis of subgenotype F1b.
Abstract: In the HCC patients, T1938C and A2051C mutations in the core region had accumulated significantly with A1762T/G1764A mutations in the basal core promoter (BCP) region and G1896A mutation in the precore (PC) region.
[Risk factors analysis and a new risk scoring system predicting hepatocarcinogenesis for chronic genotype C HBV infected patients].
PMID: 30462954
2018
Zhonghua liu xing bing xue za zhi
Abstract: In genotype C HBV infected patients, male gender, aged 40 years and over, and four DNA mutations (T1674CG, A1762T/G1764A, A3120T, and A2962G) can increase the risk of HCC (P<0.05); interferon therapy can reduce the risk of HCC (P<0.05).
Human hepatocytes apoptosis induced by replication of hepatitis B virus subgenotypes F1b and F4: Role of basal core promoter and preCore mutations.
HBV mutation literature information.
PMID: 
2019
Mediterranean journal of hematology and infectious diseases
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