Quantitative evaluation of hepatitis B virus mutations and hepatocellular carcinoma risk: a meta-analysis of prospective studies.
PMID: 26543337
2015
Chinese journal of cancer research
Abstract: CONCLUSIONS: This study demonstrated that PreS mutations, C1653T, T1753V, and A1762T/G1764A, were associated with an increased risk of HCC.
Abstract: For mutations in BCP, statistically significant pooled-RRs of HCC were obtained for T1753V (pooled-RR=2.09; 95% CI: 1.49-2.94) and A1762T/G1764A double mutations (pooled-RR=3.11; 95% CI: 2.08-4.64).
[Relationship between hepatitis B virus genotype, BCP/Pre-C region mutations and risk of hepatocellular carcinoma in Guangxi Zhuang Autonomous Region].
PMID: 26564702
2015
Zhonghua liu xing bing xue za zhi
Abstract: CONCLUSION: The present investigation showed that BCP A1762T/G1764A, A1775G and Pre-C T1858C mutations are correlated with the incidence of HCC in Fusui county of Guangxi.
Abstract: Multiple logistic regression analysis indicated that A1762T/G1764A and T1858C mutations are the risk factors for the development of HCC (OR = 5.459, 95% CI: 1.397-21.332, P = 0.015; OR = 3.881, 95% CI: 1.462-10.305, P = 0.006).
Abstract: RESULTS: The mutation rates of the A1762T/
Hepatitis B virus genotype, mutations, human leukocyte antigen polymorphisms and their interactions in hepatocellular carcinoma: a multi-centre case-control study.
Method: A risk prediction model to classify the HCC cases and controls was constructed according to the following steps: (1) Prediction factor selection: HBV genotype, the 11 independent HCC-related mutations (C1653T, C1673T, T1674C/G, C1730G, A1752G, T1753C, A1762T, G1764A, G1899A, G1915A/C and C1969T), the HLA SNPs (rs9272105 and rs9275319), the HCC-related multiplicative interactions (rs9272105 with the HBV genotype,
Deep sequencing of hepatitis B virus basal core promoter and precore mutants in HBeAg-positive chronic hepatitis B patients.
Result: Amino acid transitions induced by G1719T, A1726C, A1752G/T and BCP A1762T/G1764A mutants had higher prevalence of 39.7% (23/58), 29.3% (17/58), 27.6% (16/58) and 31.0% (18/58), which mainly occurred in genotype C (21/23), genotype B (16/17), genotype B (13/16) and genotype C (16/18) infection patients, respectively.
Result: besides classical A1762T/G1764A and G1896A mutants affecting codons 130/131 of X gene (K130M/V131I) and codon 28 of PC gene (W28stop), another 12 SN
Associations between hepatitis B virus basal core promoter/pre-core region mutations and the risk of acute-on-chronic liver failure: a meta-analysis.
Abstract: CONCLUSIONS: The HBV basal core promoter/pre-core mutations T1753V, A1762T, G1764A, C1766T, T1768A, A1846T, G1896A and G1899A, and an HBeAg-negative status correlate with an increased risk of HBV-ACLF.
Abstract: Several mutations were significantly correlated with ACLF: T1753V (1.889, 95 % confidence interval (CI) [1.357-2.631]), A1762T (2.696 [2.265-3.207]), PMID: 26571304
2015
International journal of infectious diseases
Abstract: Two-thirds of HBeAg-negative subjects with high HBV DNA levels harboured BCP (A1762T/G1764A) and/or PC (G1896A) variants.
Virological Characteristics of Acute Hepatitis B in Eastern India: Critical Differences with Chronic Infection.
Abstract: Additionally, among all substitutions, the A1762T and G1764A BCP mutations were the strongest indicators of chronicity.
Result: Major substitutions that were detectable in the BCP/PC region of acute isolates included T1753C (2.7%), A1762T/G1764A (8.1%), A18
Discussion: Moreover, we report that the highest difference in entropy was exhibited at positions A1762T and G1764A in the BCP region indicating that these two sites were most susceptible towards acquiring mutations, thus signifying that they were the strongest indicators of chronicity.
Molecular characterization of HBV strains circulating among the treatment-naive HIV/HBV co-infected patients of eastern India.
Abstract: The major mutations affecting HBeAg expression includes the A1762T/G1764A (13.6%), G1896A (22%) and G1862T mutation (33.9%) which was predominantly associated with HBV/A1.
Introduction: For example, the classical A1762T/G1764A double mutation within the basal core promoter (nt 1742-1849 from EcoRI site) and the G1896A mutation in the precore (PC) (nt 1814-1900 from EcoRI site) region are often reported to be associated with advanced liver diseases including liver cirrhosis and
Variability in the precore and core promoter region of the hepatitis B virus genome.
Abstract: The study confirmed that core promoter and precore mutations occur at key positions (A1762T, G1764A, G1896A, and G1899A), and that the proportions of strains with seroconvertion in patients differ between the four HBV genotypes.
Genetic variability of hepatitis B and C viruses in Brazilian patients with and without hepatocellular carcinoma.
Abstract: Core promoter T1753V, A1762T, and G1764A mutations were more frequent in patients with HCC than in those without, although with no statistical difference.
HBV mutation literature information.
PMID: 
2015
Chinese journal of cancer research
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