Abstract: CP mutations C1653T, T1753V, A1762T/G1764A, and C1766T/T1768A were associated with higher HBV-DNA level and increased liver disease severity.
Abstract: Multiple logistic regression analysis showed that older age (>= 40 years), male sex, high viral load (>4.3 log(10) IU/mL) and CP mutations C1653T, T1753V, A1762T/G1764A, and C1766T/T1768A were independent risk factors for Pre-core (G1896A) or Basal Core Promoter (A1762T/G1764A) Mutants.
Abstract: In conclusion, HBV basal core promoter mutations A1762T/G1764A are associated with genotype C and a low serum HBsAg level in chronically-infected HBeAg-positive Chinese patients.
Abstract: The A1762T/G1764A mutations were found to be more prevalent in genotype C than that in genotype B HBV [62.14% (64/103) vs.
Abstract: The A1762T/G1764A or G1896A mutations were detected in 125specimens (125/192, 65.10%), in which 77 (77/125, 61.60%) existed as subpopulations.
Abstract: The emergence of A1762T/G1764A mutations was also found to be assoc
Re-evaluation of the carcinogenic significance of hepatitis B virus integration in hepatocarcinogenesis.
Abstract: Furthermore, the integrated viral sequences in both groups had a similar low frequency of C1653T, T1753V and A1762T/G1764A mutations.
Result: As expected, the frequencies of C1653T, T1753V, A1762T/G1764A mutations in these 'free' HBV DNAs from both tumor derived and non-tumor derived samples were at the same level as that for the serum derived samples of the LC group and HCC group (Table 2).
Result: It is worth noting that the frequency of either C1653T or A1762T/G1764A mu
Frequency and clinical significance of core promoter and precore region mutations in Tunisian patients infected chronically with hepatitis B.
Discussion: The HBeAg negativity found in 44/49 Shongwe participants (89,7%) could be accounted for by the following HBV mutations: the basic core promoter mutations A1762T/G1764A, which can down-regulate transcription of precore mRNA; the Kozak sequence mutants that affect HBeAg translation; precore start codon mutations that abolish HBeAg expression, the G1862T mutation,which interferes with post-translational modification of the HBeAg-precursor, and the classical G1896A stop codon mutation with C1858T.
Influence of B cells in liver fibrosis associated with hepatitis B virus harboring basal core promoter mutations.
Abstract: Coefficients of logistic regression showed that the effect of increasing IgD-positive B cells in rising odds of the liver disease is the same in the patients with BCP mutation A1762T-G1764A and in the patients without mutation, nevertheless the effect of APRIL is not similar in these two groups of patients.
Abstract: Logistic regression in patients with BCP A1762T-G1764A mutations demonstrated that increasing one score of APRIL decreased the odds of fibrosis stage about 8%.
Abstract: Twenty-seven patients (47.4%) harbored the A1762T-G1764A BCP mutations.
Effects of antiviral therapy on the recurrence of hepatocellular carcinoma after curative resection or liver transplantation.
Introduction: A1762T/G1764A in liver tissue can independently predict postoperative survival.
Introduction: C1653T, T1753V, A1762T/G1764A, T1674C/G, C1766T/T1768A, T53C, preS2 start codon mutation, preS1 deletion, C2964A, A2962G, C3116T, C7A, and their combinations are HBV mutations that are significantly associated with an increased risk of HCC occurr
Correlation between hepatitis B virus genotypes and clinical outcomes.
PMID: 23183198
2012
Japanese journal of infectious diseases
Abstract: Accumulating evidence indicated that higher plasma HBV DNA levels, infection with HBV genotype C, as well as mutations at 1653T, 1753V, and A1762T/G1764A are independently associated with the risk of HCC in Asian men.
[Analysis of the relationship between hepatitis B virus precore and basal core promoter mutations and acute-on-chronic liver failure].
Abstract: Single mutations (A1762T, G1764A, T1753V, G1896A, and G1899A) and combined mutations (A1762T + G1764A, G1896A + G1899A, T1753V+ A1762T + G1764A, G1896A + G1899A + A1762T + G1764A, and A1762T + G1764A + G1896A) were more frequently detected in HB-ACL
Differences in HBV Replication, APOBEC3 Family Expression, and Inflammatory Cytokine Levels Between Wild-Type HBV and Pre-core (G1896A) or Basal Core Promoter (A1762T/G1764A) Mutants.
PMID: 23304671
2012
Iranian journal of public health
Abstract: BACKGROUND: To glean insights into the relationship among hepatitis B virus (HBV) genotype/subgenotypes, A1762T/G1764A mutations and advanced liver disease such as liver cirrhosis (LC) and hepatocellular carcinoma (HCC) in Southeast China.
Abstract: Both subgenotype C2 infection and A1762T/G1764A mutations were associated with LC and HCC with cirrhosis, subgenotype C2 (OR=2.033, 95%CI=1.246-3.323, P=0.003 for
ViMRT
HBV mutation literature information.
PMID: 
2012
PloS one
