Hepatitis B virus genotypes, precore mutations, and basal core promoter mutations in HBV-infected Chinese patients with persistently normal alanine aminotransferase and low serum HBV-DNA levels.
PMID: 22358356
2012
The Brazilian journal of infectious diseases
Abstract: The most common mutations were G1896A (23.6%), G1764A (9.0%), and A1762T (6.7%).
Genetic analysis of precore/core and partial pol genes in an unprecedented outbreak of fulminant hepatitis B in India.
Abstract: A1762T, G1764A basal core promoter (BCP) mutations, insertion of isoleucine after nt 1843, stop codon mutation G1896A, G1862T transversion plus seven other mutations in the core gene caused inhibition of HBeAg expression implicating them as circulating precore/BCP mutant virus.
Natural history of chronic hepatitis B: what exactly has REVEAL revealed?
Abstract: Genetic features including HBV genotype and basal core promoter A1762T/G1764A mutant, and precore G1896A mutant were documented as predictors of HCC risk.
Dynamics of hepatitis B virus quasispecies in association with nucleos(t)ide analogue treatment determined by ultra-deep sequencing.
Introduction: For example, in chronic infection, G to A point mutation at nucleotide (nt) 1896 in the pre-core (
Result: Emergence of G1896A mutation in the pre-C region, and A1762T and G1764A mutations in the core-promoter region is well known to be associated with HBe-seroconversion.
Result: These findings suggested that other mutations except G1896A, A1762T and G1764A were also involved in the HBeAg seroconversion status.
Table: G1764A
HBV genotypes prevalence, precore and basal core mutants in Morocco.
PMID: 22579480
2012
Infection, genetics and evolution
Abstract: BCP mutants were observed in 65.7% of cases, 22.9% were found to have the T1762/1764A double mutation, 18.6% had A1762/1764T mutation and 22.9% of patients showed the A1762T/G1764A double mutation with either A1762T/G1764T mutation.
Precore mutation of hepatitis B virus may contribute to hepatocellular carcinoma risk: evidence from an updated meta-analysis.
Abstract: Similar correlation existed between BCP double mutation A1762T/G1764A, T1753V, C1653T and HCC.
Discussion: Besides, G1899A, Pre-S1 deletion, Pre-S2 deletion as well as other common mutations like BCP double mutation A1762T/G1764A, T1753V and C1653T, all of them correlate with HCC risk.
Discussion: For the other common mutations, BCP double mutation
[Analysis of the complete hepatitis B virus genomes in a patient for repeated seroconversion to anti-HBe antibody due to co-infection with two virus clones].
PMID: 22686039
2012
Rinsho byori. The Japanese journal of clinical pathology
Abstract: However, both clones had mutations in the core promoter(A1762T, G1764A).
A multicentre molecular analysis of hepatitis B and blood-borne virus coinfections in Viet Nam.
Figure: In contrast, the basal core promoter mutations Discussion: Although the numbers were too low to reach statistical significance, we also identified a difference in the G1896A and A1762T/G1764A mutations at the subgenotype level, which has also been previously reported.
Discussion: Genetic mutations and deletions in the pre-S and basal core promoter regions of the HBV genome including T1753V, A1762T, G1764A, and C1766T have been associated with more severe liver disease and the development of HCC.
Hepatitis B virus gene mutations in liver diseases: a report from New Delhi.
Abstract: Cells bearing the constructs with double mutations A1762T/G1764A contained the lowest levels of hepatitis B e antigen (HBeAg).
Abstract: Lowest expression of HBV X protein was in constructs that had both A1762T/G1764A and 1726-1730 CTGAG mutations.
Abstract: The double mutation A1762T/G1764A increased whereas the nt 1726-1730 CTGAG mutations decreased the levels of released virion-associated and intracellular HBV DNA.
Abstract: To confirm the effects of these mutations on the virus replication efficiency, substitutions nt 1726-1730 CTGAG and A1762T/G1764A in the HBV
HBV mutation literature information.
PMID: 
2012
The Brazilian journal of infectious diseases
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