Abstract: BACKGROUND: A double variant in the basal core promoter, converting nucleotide 1762 from A to T (T1762) and nucleotide 1764 from G to A (A[764), has been described in patients with chronic hepatitis B infection.
Age at time of hepatitis Be antibody seroconversion in childhood chronic hepatitis B infection and mutant viral strain detection rates.
PMID: 10554127
1999
Journal of pediatric gastroenterology and nutrition
Abstract: Specifically, a mutant strain showing a G-to-A substitution at nucleotide 83 in the pre-C region, or a mutant strain showing an A-to-T substitution at nucleotide 1762 and a G-to-A substitution at nucleotide 1764, was detected in only two of eight cases (25%) from the HBeAb-positive carriers with documented seroconversion before age 6.
Abstract: The most frequently described mutations within this region are an A to T transversion at position 1762 together with a G to A transition at position 1764.
[Dynamic changes of basal core promoter and pre-core mutants of hepatitis B virus in patients with chronic hepatitis B virus infection].
PMID: 12759956
1999
Zhonghua shi yan he lin chuang bing du xue za zhi
Abstract: Using two mis-matched primers to amplify BCP and pre-c gene fragments, in combination with restricted fragment length polymorphism assay, we studied the presence of these two mutants(nt 1762A-->T, 1764G-->A and nt1896G-->A) in 105 serum samples.
Differences in HBV Replication, APOBEC3 Family Expression, and Inflammatory Cytokine Levels Between Wild-Type HBV and Pre-core (G1896A) or Basal Core Promoter (A1762T/G1764A) Mutants.
PMID: 9472623
1998
The Journal of general virology
Abstract: Hepatitis B virus (HBV) isolates with A-1762 to T and G-1764 to A mutations in the core promoter have been associated with active hepatitis, severe liver disease following liver transplantation, hepatocellular carcinoma and acute fulminant courses--in the latter case combined with a C-1653 to T mutation.
Association of mutations in the core promoter and precore region of hepatitis virus with fulminant and severe acute hepatitis in Japan.
PMID: 9870800
1998
Journal of gastroenterology and hepatology
Abstract: The presence of HBV mutants was examined by using a point mutation assay to detect a G to A transition at position 1896 in the precore region and an A to T transition at position 1762 and a G to A transition at position 1764 in the core promoter region.
Effects of a frequent double-nucleotide basal core promoter mutation and its putative single-nucleotide precursor mutations on hepatitis B virus gene expression and replication.
PMID: 9267007
1997
The Journal of general virology
Abstract: A double mutation in the BCP which converts nucleotide (nt) 1762 from A to T and nt 1764 from G to A is frequently observed in patients with chronic hepatitis B.
Reduced precore transcription and enhanced core-pregenome transcription of hepatitis B virus DNA after replacement of the precore-core promoter with sequences associated with e antigen-seronegative persistent infections.
Abstract: Especially, A to T mutations at nucleotide 1762 and G to A mutations at nucleotide 1764 were found in five anti-HBe-positive asymptomatic carriers, and 22 patients with chronic liver disease.
Hepatitis B virus core promoter sequence analysis in fulminant and chronic hepatitis B.
Abstract: BACKGROUND & AIMS: It was recently reported that two point mutations within the hepatitis B virus (HBV) core promoter region (A to T at position 1762 and G to A at position 1764) are associated with fulminant hepatitis and lead to hepatitis B e antigen (HBeAg)-negative phenotype.
HBV mutation literature information.
PMID: 
1999
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