Method: The methods to detect HBV basal core promoter (BCP) A1762T/G1764A mutations, precore stop codon G1896A mutation and pre-S deletion were performed as previously described.
Result: The genotypic characteristics of these 51 HBVCI patients were also assayed, including genotype, precore stop codon G1896A mutation, BCP A1762T/G1764A mutation, pre-S deletion mutation and sequence analysis of the whole S coding region (Ta
Role of viral genotypes and hepatitis B viral mutants in the risk of hepatocellular carcinoma associated with hepatitis B and C dual infection.
Abstract: CONCLUSIONS: Pre-S deletion, A1762T/G1764A mutation and HCV genotype-1 are important in hepatocarcinogenesis in chronic HBV/HCV dual infection.
Abstract: In the nested case-control study, patients with HCC had a higher HBV DNA level (p < 0.001), a higher frequency of pre-S deletion (p < 0.001) and A1762T/G1764A mutant (p = 0.005), a lower HCV RNA level (p = 0.012) and a higher prevalence of HCV genotype-1 (p = 0.002) than those without.
Abstract: Patients with combined HBV mutations (pre-S deletion and A1762T/
A complete genomic analysis of hepatitis B virus isolated from 516 Chinese patients with different clinical manifestations.
Abstract: Incidences of point mutation T53C (preS1F53L), G1613A (polR841K), G1775A and A1762T + G1764A in the basal core promoter region, G1896A and G1899A in precore region and A2189C (coreI97L) in core region increased along with acute hepatitis B, chronic hepatitis B, and acute-on-chronic liv
Molecular characterization of hepatitis B virus in liver disease patients and asymptomatic carriers of the virus in Sudan.
Result: A1762T/G1764A was found in 11 G1896A mutants and in one T1815C mutant.
Result: One genotype A isolate from a HBeAg-positive patient, (SDAC108) had A1762T/G1764A.
Result: One isolate had wild-type BCP/PC region, two had A1762T/G1764A, one with G1862T and the fourth isolate had G1862T alone.
Result: Six isolates from HBeAg-negative sera had A1762T/G1764A alone.
Discussion: Other mut
Positive selection signals of hepatitis B virus and their association with disease stages and viral genotypes.
PMID: 23871771
2013
Infection, genetics and evolution
Abstract: Moreover, we found that three substitutions, including A1762T, G1764A, and A2739C, were nearly fixed.
Hepatitis B virus genetic variation and TP53 R249S mutation in patients with hepatocellular carcinoma in Thailand.
PMID: 23886144
2013
Asian Pacific journal of cancer prevention
Abstract: By multiple logistic regression analysis, the presence of A1762T/G1764A mutations was independently associated with the risk of HCC in Thai patients.
Abstract: The prevalences of T1753C/A/G and A1762T/G1764A mutations in the basal core promotor (BCP) region were significantly higher in the HCC group compared to the non-HCC group.
Hepatitis B virus subgenotype C2- and B2-associated mutation patterns may be responsible for liver cirrhosis and hepatocellular carcinoma, respectively.
PMID: 23903686
2013
Brazilian journal of medical and biological research
Abstract: Multivariate regression analyses showed that HBV subgenotype C2 and C2-associated mutation patterns (C1653T, T1753C, A1762T, and G1764A) were independent risk factors for LC when CHB was the control, and that B2-associated mutation patterns (C1810T, A1846T, G1862T, and G1896A) were independent risk factors for HCC when LC was the control.
Molecular characterisation of hepatitis B virus in the resident Chinese population in Panama City.
PMID: 23903967
2013
Memorias do Instituto Oswaldo Cruz
Abstract: Additionally, the mutation pair A1762T/G1764A was found in three samples and the mutation G1896A was detected in an HBeAg-negative subject.
Result: The analysis of mutations in the Enh II, PC and BCP regions of the 10 samples revealed the following results: the mutation
Discussion: The mutation pair A1762T/G1764A was found in three samples, with one sample concurrently showing the BCP mutation G1896A; this group of mutations abolished the secretion of HBeAg in this specimen, as evidenced by a negative result in the immunoassay used.
Variability of the preC/C region of hepatitis B virus genotype A from a South African cohort predominantly infected with HIV.
Conclusion: Also the basal core promoter region of HBV genome was not sequenced in this study, therefore, the prevalence of A1762T and G1764A mutations could not be determined.
Discussion: Most published data state that HBeAg-negative chronic hepatitis B due to preC mutations is common in non-A genotypes only, and that mutations that often lead to reduced production of HBeAg in genotype A are confined to the core promoter region (A1762T and G1764A).
Hepatitis B virus in the State of Alagoas, Brazil: genotypes characterization and mutations of the precore and basal core promoter regions.
PMID: 24021712
2013
The Brazilian journal of infectious diseases
Abstract: The aims of this study were to investigate the genotypes of hepatitis B virus and to identify the precore G1896A and basal core promoter A1762T/G1764A mutations in HBsAg and anti-HBc-positive patients.
HBV mutation literature information.
PMID: 
2013
PloS one
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