Abstract: When analyzing the basal nucleus promoter, Precore and Core regions, 22.2% of patients with the double mutation A1762T / G1764A, 25% with the mutation G1896A were identified.
Case Report: Application of hepatitis B virus (HBV) deep sequencing to distinguish between acute and chronic infection.
Abstract: Through application of deep whole-genome sequencing we typed the isolate as genotype-D1, and identified several minority variants including G1764A and G1986A substitutions in the pre-core promoter and pre-core regions, which support CHB-AR rather than AHB.
Conclusion: The most prevalent minority variant mutations in our HBV sequences were G1896A, G1899A and G1764A (precore/core and basal core promotor sequences respectively) ( Table 1).
Table: G1764A
Comprehensive Analysis of Clinically Significant Hepatitis B Virus Mutations in Relation to Genotype, Subgenotype and Geographic Region.
Abstract: HCC-associated mutations were detected in 33.7% of the sequences, with significantly higher frequency of C1653T, T1753V and A1762T/G1764A in genotype G than C (P < 0.001).
Discussion: A previous meta-analysis showed that Pre-S deletions, C1653T in enhancer II, and T1753V and A1762T/G1764A in BCP are associated with increased risk of HCC compared with HBV without mutations.
Discussion: Consistently, genotype H showed the lowest rates of
Viral hepatitis B and C in HIV-exposed South African infants.
5Result: The ""Week 0"" Cape Town sample showed a similar serological profile to the ""Week 48"" sample from the same child and also had the double A1762T/G1764A BCP mutation."
Abstract: The Result: Both sequences harboured the double A1762T/G1764A BCP mutation.
Result: Sequence analysis revealed the M204I mutation in the reverse transcriptase domain of the polymerase gene in the Durban sample while the Cape Town sample harboured the double A1762T/G1764A BCP mutation in the core gene.
Quadruple mutation GCAC1809-1812TTCT acts as a biomarker in healthy European HBV carriers.
Abstract: Calculation of the pgRNA secondary structure suggests a destabilization of the pgRNA structure by A1762T/G1764A that was compensated by GCAC1809-1812TTCT.
Abstract: GCAC1809-1812TTCT was strongly associated with coexistence of basal core promoter (BCP) double mutation A1762T/G1764A and lower HBV DNA levels.
Introduction: For example, the double mutation A1762T/G1764A is the most common mutation in BCP and was found in some studies to be associated with progression to advanced liver disease and HCC development.
Introduction: However, altho
High possibility of hepatocarcinogenesis in HBV genotype C1 infected Cambodians is indicated by 340 HBV C1 full-genomes analysis from GenBank.
Result: 2), among the 16 isolates from our study located in cluster c, 15 isolates had the A1762T/G1764A mutation and 12 isolates had combination mutation (Table 3).
Result: Based on the presence or absence of the mutations of pre-S deletion, G1613A, C1653T, T1753V, A1762T/G1764A, Pre-C W28 stop codon, and P130, these 340 genotype C1 strains were classified in 48 patterns.
Result: Combination mutation at T1753V and A1762T/G1764A was most frequent.
Result: double mutation at
rt269I Type of Hepatitis B Virus (HBV) Leads to HBV e Antigen Negative Infections and Liver Disease Progression via Mitochondrial Stress Mediated Type I Interferon Production in Chronic Patients With Genotype C Infections.
Result: In double mutations in BCP, only the G1764A mutation, but not the A1762T, was significantly prevalent in patients with rt269I of both our cohort and GenBank.
Result: Of the various HBV mutations, G1896A mutations on the pre-core region (preC mutation) and A1762T/G1764A double mutations on the basal core promoter (BCP) lead to HBeAg negative infection that are significantly related to liver disease progression.
Table: G1764A
Next generation sequencing identifies baseline viral mutants associated with treatment response to pegylated interferon in HBeAg-positive chronic hepatitis B.
Abstract: Based on NGS, the prevalence of T1753V (T1753C/A/G) and A1762T/G1764A variants were significantly lower in responders compared to non-responders (8.3% vs.
Abstract: The absence of T1753V and A1762T/G1764A mutations were factors associated with CR (OR 11.65, 95%CI 1.36-100.16, P = 0.025, and OR 4.36, 95%CI 1.08-17.63, P = 0.039, respectively).
Abstract: The existence of pre-treatment T1753V, A1762T/G1764A mutations and their combination yielded negative predictive values of 94.7%, 85.7% and 93.8%, respectively.
Locus 5p13.1 may be associated with the selection of cancer-related HBV core promoter mutations.
PMID: 31341412
2019
International journal of medical sciences
Introduction: The precore mutation (G1896A), mutations in enhancer II (C1653T) and the BCP (T1753V and the double mutations, A1762T, G1764A), and deletions in the pre-S region have been reported to be associated with the development of
Discussion: In summary, our study provides evidence using GWAS that host genetic polymorphisms are associated with the immune selection of HCC-related double mutations (A1762T and G1764A) in the basal core promoter of HBV.
Large-scale viral genome analysis identifies novel clinical associations between hepatitis B virus and chronically infected patients.
Discussion: Previous studies described additional variants in the core promoter including C1653T, T1753C, A1762T, and G1764A and their correlation with the downregulation of precore mRNA.
Discussion: While our study did not identify any significant association with A1762T and G1764A, we found T1753C to be strongly associated with HBeAg status in our dataset (Supplementary Table 2).
HBV mutation literature information.
PMID: 
2020
Klinicheskaia laboratornaia diagnostika
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