literature

HBV mutation literature information.

HBx mutants differentially affect the activation of hypoxia-inducible factor-1alpha in hepatocellular carcinoma.

PMID: 24346287 2014 British journal of cancer

Result: It was particularly interested to find that mutants A1630G and G1721A always appeared concurrently and that mutant A1762T constantly accompanied mutant G1764A.

Result: The dual mutations at nucleotides A1762T/G1764A affected the codons of HBx, resulting in a lysine to methionine change at codon 130 and a valine to isoleucine change at codon 131 (K130M/V131I).

Result: Therefore, these findings indicated that the dual point mutations A1762T/G1764A, which result in mutated K130M/<

Differences in HBV Replication, APOBEC3 Family Expression, and Inflammatory Cytokine Levels Between Wild-Type HBV and Pre-core (G1896A) or Basal Core Promoter (A1762T/G1764A) Mutants.

PMID: 24389280 2014 The Brazilian journal of infectious diseases

Abstract: However, the percentage of A1762T/G1764A double mutation in hepatitis B e antigen-negative (58.3%) samples was almost the same as in hepatitis B e antigen-positive (61%) samples.

Abstract: METHODS: We developed an accurate and fast real-time amplification refractory mutation system to detect A1762T/G1764A double mutation.

Abstract: OBJECTIVE: To study the role of hepatitis B virus with A1762T/G1764A double mutation in liver cirrhosis and hepatocellular carcinoma, and create a sensitive, fast, accurate assay for detection of A1762T/

Analysis of complete nucleotide sequences of Angolan hepatitis B virus isolates reveals the existence of a separate lineage within genotype E.

PMID: 24632784 2014 PloS one

Result: The common variations A1762T-G1764A in the basal core promoter and G1896A and G1899A in the precore region were identified in three, four and two isolates, respectively.

Table: G1764A

Mutation profiling of the hepatitis B virus strains circulating in North Indian population.

PMID: 24637457 2014 PloS one

Discussion: K130M and V131I are translated due to basal core promoter mutations Adenine to Threonine at nucleotide position 1762 (A1762T) and Guanosine to Adenine at nucleotide position 1764 (

Discussion: However, quarter of HBeAg negative isolates has genotype A (A1762T and G1764A) HBV infection (Basal Core Promoter mutation)

Discussion: However, quarter of HBeAg negative isolates has genotype A (A1762T and G1764A) HBV infection (Basal Core Promoter mutation).

Novel natural mutations in the hepatitis B virus reverse transcriptase domain associated with hepatocellular carcinoma.

PMID: 24788140 2014 PloS one

Introduction: A recent meta-analysis including a total of 11,582 HBV-infected participants revealed that deletions in the pre-S gene and mutations of C1653T, T1753V and A1762T/G1764A in the basal core promoter (BCP)/enhancer II (EnhII) region had statistically significant summary odds ratios (OR) for HCC.

Molecular epidemiological study of hepatitis B virus genotypes in Southwest, China.

PMID: 24797477 2014 Journal of medical virology

Abstract: 67.5% (56/83) of genotype C/D was Hepatitis B surface antigen (HBsAg) positive/Hepatitis B e antigen (HBeAg) positive/HBV DNA>=20,000 IU/ml, BCP A1762T/G1764A double mutation was frequent in genotype C and C/D, and G1896A was frequent in B and B/C.

Abstract: C/D recombinant exhibits higher frequency with HBeAg positive, high level of HBV DNA and BCP A1762T/G1764A double mutation.

Abstract: HBV infectious markers, HBV DNA and mutations in the basic core promoter (BCP) <

Mother-to-child transmission of hepatitis B virus: evolution of hepatocellular carcinoma-related viral mutations in the post-immunization era.

PMID: 24973814 2014 Journal of clinical virology

Abstract: In the 56 mother-child pairs with 1-15 year-old children acquired the infection from their mothers, the frequencies of HBV mutations including A1762T/G1764A and G1896A in genotype B2 or C2 increased consecutively with increasing age of children.

Abstract: The HCC-risk mutations including A1762T/G1764A were present in the mothers' and cord blood but mostly absent in the 7-month-old infants'.

Abstract: These mutations including A1762T/G1764A in genotype C2 and G1896A in genotype B2 were more frequent in mothers than in children (P<0.001).

Effect of functional nuclear factor-kappaB genetic polymorphisms on hepatitis B virus persistence and their interactions with viral mutations on the risk of hepatocellular carcinoma.

PMID: 25223483 2014 Annals of oncology

Abstract: In the genotype C HBV-infected subjects, rs2233406 variant genotypes were significantly associated with an increased risk of HCC [CT versus CC: age-, gender-adjusted odds ratio (AOR), 1.33; 95% confidence interval (CI) 1.01-1.75 in training set and AOR, 1.59; 95% CI 1.01-2.52 in validation set] compared with HCC-free HBV-infected subjects and significantly increased the frequencies of HCC-related HBV mutations (A1762T/G1764A, T1753V, preS1 start codon mutation, and preS deletion); rs28362491 (Del/Del or Ins/Del + Del/Del versus Ins/Ins) signific

Hepatitis B virus genotype B and mutations in basal core promoter and pre-core/core genes associated with acute-on-chronic liver failure: a multicenter cross-sectional study in China.

PMID: 26202756 2014 Hepatology international

Abstract: A multivariate analysis showed that factors such as HBV genotype B, age >=40 years and A1762T/G1764A, A1846T and G1896A mutations were independently associated with the development of HB-ACLF.

Abstract: CONCLUSION: Chronic HBV infection with genotype B, A1762T/G1764A, A1846T a

Abstract: Comparing with CHB-S, the A1762T/G1764A mutation in genotype B and the A2159G mutation in genotype C were significantly more common in HB-ACLF patients.

S gene mutants occurrence among hepatitis B carriers in malaysia.

PMID: 25737728 2014 Hepatitis monthly

Result: Among the basal core promoter mutations, A1762T-G1764A double mutation was present in 26.9%, C1653T in 8.6%, A1752G in 10.8% and C1766T in 2.2% of the isolates.

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