literature

HBV mutation literature information.

Lower mutation frequency of BCP/precore regions in e antigen-negative chronic HBV-infected children instead of adults patients.

PMID: 25822176 2015 PloS one

Discussion: An A1762T/G1764A double mutation in the BCP/precore region would reduce the levels of HBeAg by inhibiting precore mRNA expression, leading to the transition from the immune tolerance to the immune reactive phase, followed by lower DNA viral loads and elevated ALT levels.

Discussion: Deletions in core regions instead of the G1896A and A1762T/G1764A double mutation were observed in early seroconversion processes in a longitudinal study of infants (our own unpublished data), which also supports the idea that HBeAg seroconversion does not solely rely on BCP

Hepatitis B virus genotype distribution and genotype-specific BCP/preCore substitutions in acute and chronic infections in Argentina.

PMID: 25822666 2015 PloS one

Introduction: Based on the stability of the encapsidation signal (nt 1847-1907) it has been established that genotypes carrying 1858T (B, C2, C3, D, E, F1 and F4) favor the emergence and selection of G1896A, whereas the double mutation A1762T/G1764A in the BCP is more prone to occur in those genotypes carrying 1858C (A, C1, F2, F3 and H).

Result: In brief, those patients infected with sgF4 and gD mutated G1896A more frequently than A1762T/G1764A (p = 0.007 and p<0.001 respectively), whereas those patients carrying sgF1b and sgA2 had the opposite mutation pattern, showing higher rates of mutations in positions 1762 and 1764 than in 1896 (p = 0.013 and p = 0.010 respectively).

Result: In spite of the low prevalence of mutations in

Phosphatase and tensin homologue genetic polymorphisms and their interactions with viral mutations on the risk of hepatocellular carcinoma.

PMID: 25881591 2015 Chinese medical journal

Introduction: We and others have reported that HBV mutations C1653T, T1753V, A1762T/G1764A, T1674C/G, and C1766T/T1768A in the enhancer II/basal core promoter (EnhII/BCP) region; G1899A, C2002T, A2159G, A2189C, and G2203A/T in the precore/core region; as well as T53C,

PMID: 25926495 2015 Journal of clinical microbiology

Abstract: A triple mutation (A1762T/G1764A/G1896A) was observed more frequently in genotype C than in genotype B.

Associations between hepatitis B virus basal core promoter/pre-core region mutations and the risk of acute-on-chronic liver failure: a meta-analysis.

PMID: 26063382 2015 Virology journal

Abstract: CONCLUSIONS: The HBV basal core promoter/pre-core mutations T1753V, A1762T, G1764A, C1766T, T1768A, A1846T, G1896A and G1899A, and an HBeAg-negative status correlate with an increased risk of HBV-ACLF.

Abstract: Several mutations were significantly correlated with ACLF: T1753V (1.889, 95 % confidence interval (CI) [1.357-2.631]), A1762T (2.696 [2.265-3.207]),

PMID: 26165271 2015 Molecular medicine reports

Abstract: The double nucleotide, A1762T and G1764A exchange (TA mutation), in the hepatitis B virus (HBV) genome basal core promoter (BCP) region is a common viral mutation in patients with chronic HBV infection.

Deep sequencing of hepatitis B virus basal core promoter and precore mutants in HBeAg-positive chronic hepatitis B patients.

PMID: 26647737 2015 Scientific reports

Result: Amino acid transitions induced by G1719T, A1726C, A1752G/T and BCP A1762T/G1764A mutants had higher prevalence of 39.7% (23/58), 29.3% (17/58), 27.6% (16/58) and 31.0% (18/58), which mainly occurred in genotype C (21/23), genotype B (16/17), genotype B (13/16) and genotype C (16/18) infection patients, respectively.

Result: besides classical A1762T/G1764A and G1896A mutants affecting codons 130/131 of X gene (K130M/V131I) and codon 28 of PC gene (W28stop), another 12 SN

Distribution of hepatitis B virus genotype and cancer predicting precore and basal core promoter mutations.

PMID: 26288490 2015 Medical journal, Armed Forces India

Abstract: The total Double mutations of BCP at A1762T/G1764A nucleotide positions, and PC mutation at G1896A nucleotide position were seen in 29.3% and 21.3%, respectively.

Abstract: Viral factors that may increase the risk for HCC development include HBV DNA level, genotypes, and naturally occurring mutations such as hepatitis B virus precore (PC) (G1896A) and basal core promoter (BCP) A1762T/G1764A double mutations.

Hepatitis B Virus Combo Mutations Improve the Prediction and Active Prophylaxis of Hepatocellular Carcinoma: A Clinic-Based Cohort Study.

PMID: 26290395 2015 Cancer prevention research (Philadelphia, Pa.)

Abstract: In control patients carrying A1762T/G1764A, addition of C1653T and/or T1753V significantly increased HCC risk (HR, 1.57; P = 0.038); combo mutations with C1653T, T1753V, and A1762T/G1764A improved the validity of HCC prediction by age, male, and cirrhosis (P = 0.002).

Abstract: In summary, HBV mutation A1762T/G1764A, C1653T, and T1753V in combination improve

PMID: 26447624 2015 Zhonghua gan zang bing za zhi

Abstract: CONCLUSION: Incidence of the T1674C mutation in the X region and of the T1753C mutation and the A1762T/G1764A double mutation in the BCP region was higher for patients with HBV-related HCC; the T1753C mutation and the A1762T/G1764A double mutation may inhibit the formation of HBeAg.

Abstract: Prevalence of the T1753C mutation and the A1762T/G1764A double mutation in the BCP region was significantly higher in the

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